Document Detail


Ambulatory blood pressure monitoring in obese children: role of insulin resistance.
MedLine Citation:
PMID:  17082726     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To investigate the relationship between ambulatory blood pressure (ABPM) parameters and insulin resistance in obese children. METHODS: A population of 56 obese prepubertal children was recruited for the study. They underwent ABPM, an oral glucose tolerance test and complete physical examination, including adiposity indexes such as body mass index (BMI), skinfolds, waist-to-hip ratio (WHR) and fat mass. RESULTS: The standard deviation score for BMI was significantly correlated with 24-h systolic blood pressure (SBP) (r = 0.30; P = 0.02) and diastolic blood pressure (DBP) (r = 0.29; P = 0.03), daytime SBP and DBP (r = 0.28; P = 0.04 and r = 0.32; P = 0.02), night-time SBP and DBP (r = 0.32; P = 0.01 and r = 0.27; P = 0.04). Fat mass was correlated with 24-h SBP (r = 0.46; P = 0.005), daytime SBP (r = 0.40; P = 0.01) and night-time SBP (r = 0.49; P = 0.03). No correlations were found between ABPM parameters and WHR. Furthermore, significant correlations were found between insulin resistance indexes, such as the homeostasis model assessment of insulin resistance and quantitative insulin-sensitivity check index, and 24-h DBP (r = 0.34; P = 0.01 and r = -0.29; P = 0.03), daytime DBP (r = 0.35; P = 0.009 and r = -0.34; P = 0.01) and daytime SBP (r = 0.32; P = 0.02 and r = -0.27; P = 0.04). Only 24-h and daytime DBP remained correlated with insulin resistance after adjustment for obesity. The analysis of the circadian rhythm of blood pressure revealed that 24 out the 56 children were non-dippers. CONCLUSIONS: The results of the present study indicate that adiposity and insulin resistance have an important role in influencing blood pressure in obese children, and also show a high prevalence of non-dipping phenomenon. This is of particular relevance because blood pressure tracks from childhood into adulthood and an already early-life high blood pressure is associated with an increased cardiovascular risk.
Authors:
Maria L Marcovecchio; Luca Patricelli; Michele Zito; Rita Capanna; Mariapaola Ciampani; Francesco Chiarelli; Angelika Mohn
Related Documents :
8576896 - Is isolated systolic hypertension in the elderly more associated with left ventricular ...
16107856 - High blood pressure is inversely related with the presence and extent of coronary colla...
17693826 - Hypotension begins at 110 mm hg: redefining "hypotension" with data.
3221376 - Nutritional correlates of blood pressure in elderly chinese.
17714086 - Indices of vascular stiffness and wave reflection in relation to body mass index or bod...
8356016 - The effects of hypoxic acidemia on left ventricular end-systolic elastance in fetal sheep.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of hypertension     Volume:  24     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-03     Completed Date:  2007-10-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  2431-6     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, University of Chieti, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Blood Pressure / physiology*
Blood Pressure Monitoring, Ambulatory*
Child
Child, Preschool
Female
Humans
Insulin Resistance / physiology*
Male
Obesity / physiopathology*
Comments/Corrections
Comment In:
J Hypertens. 2007 Mar;25(3):723; author reply 723-4   [PMID:  17278991 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Simvastatin treatment modifies polymorphonuclear leukocyte function in high-risk individuals: a long...
Next Document:  Baroreflex sensitivity improvement is associated with decreased oxidative stress in trained spontane...