Document Detail

Ambulatory blood pressure as predictor of preeclampsia in diabetic pregnancies with respect to urinary albumin excretion rate and glycemic regulation.
MedLine Citation:
PMID:  11846705     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Twenty-four-hour ambulatory blood pressure was evaluated as a predictor of preeclampsia in women with insulin-dependent diabetes mellitus with respect to urinary albumin excretion rate and glycemic regulation. METHODS: One hundred and fifty-one women with insulin-dependent diabetes mellitus were consecutively recruited from the outpatient maternity ward for 24 hour ambulatory blood pressure measurement with a portable monitor (SpaceLab 90207). Blood pressure was measured three times during pregnancy and once after delivery. Evaluation was performed with receiver-operator-characteristics curves in primiparous women. Stratified analysis and multiple regression was applied with respect to urinary albumin excretion rate, HbA1c, age, duration of diabetes mellitus, uric acid, and BMI. RESULTS: The incidence of preeclampsia was significantly associated with increasing urinary albumin excretion rate, primiparity, and ambulatory blood pressure. Ambulatory blood pressure was associated with HbA1c throughout pregnancy adjusted for urinary albumin excretion rate. The ambulatory blood pressure was higher from first trimester throughout pregnancy in women developing preeclampsia compared to women who did not have preeclampsia. The best sensitivity and specificity for predicting preeclampsia in primiparous women were at cut-off values of systolic and diastolic day ambulatory blood pressure above 122 and 74 mmHg, respectively. The relative risk of preeclampsia was significantly higher when ambulatory blood pressure was above the cut-off values and increased further with higher urinary albumin excretion rate. CONCLUSIONS: The relationship between ambulatory blood pressure and preeclampsia is not confined to women with macroalbuminuria but is also present in women with normo- and microalbuminuria. Poor glycemic control and increased urinary albumin excretion rate is associated with preeclampsia when ambulatory blood pressure is above cut-off values of 122/74 mmHg (systole/diastole). Ambulatory blood pressure is a reliable measurement for prediction of preeclampsia in primiparous women with insulin-dependent diabetes mellitus.
F F Lauszus; O W Rasmussen; T Lousen; T M Klebe; J G Klebe
Related Documents :
3555005 - Therapy of non-preeclamptic hypertension in pregnancy.
20214375 - Modeling spatial establishment patterns of exotic forest insects in urban areas in rela...
6846435 - Preliminary evidence of the effect of calcium supplementation on blood pressure in norm...
20051605 - Predictors of change in grip strength over 3 years in the african american health project.
21547885 - Intramucosal carbon dioxide partial pressure measurement rescued the reconstructed gast...
3195805 - Exponential analysis of the pressure-volume curve. correlation with mean linear interce...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  80     ISSN:  0001-6349     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2002-02-15     Completed Date:  2002-03-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  1096-103     Citation Subset:  IM    
Gynecological/Obstetrical Department Y, Skejby Hospital, Aarhus, Denmark.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Albuminuria / urine*
Birth Weight
Blood Glucose / metabolism*
Blood Pressure / physiology*
Blood Pressure Monitoring, Ambulatory
Creatinine / urine
Diabetes Mellitus, Type 1 / blood,  physiopathology*,  urine
Hemoglobin A, Glycosylated / metabolism
Infant, Newborn
Pre-Eclampsia / blood,  diagnosis*,  urine
Pregnancy in Diabetics / blood,  complications*,  urine
Prospective Studies
ROC Curve
Regression Analysis
Sensitivity and Specificity
Uric Acid / blood
Reg. No./Substance:
0/Blood Glucose; 0/Hemoglobin A, Glycosylated; 60-27-5/Creatinine; 69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Perinatal deaths and insufficient antenatal care in Latvia.
Next Document:  Four years experience of first-trimester nuchal translucency screening for fetal aneuploidies with i...