Document Detail

Ambulatory versus home versus clinic blood pressure: the association with subclinical cerebrovascular diseases: the Ohasama Study.
MedLine Citation:
PMID:  22083163     Owner:  NLM     Status:  MEDLINE    
The usefulness of ambulatory, home, and casual/clinic blood pressure measurements to predict subclinical cerebrovascular diseases (silent cerebrovascular lesions and carotid atherosclerosis) was compared in a general population. Data on ambulatory, home, and casual/clinic blood pressures and brain MRI to detect silent cerebrovascular lesions were obtained in 1007 subjects aged ≥55 years in a general population of Ohasama, Japan. Of the 1007 subjects, 583 underwent evaluation of the extent of carotid atherosclerosis. Twenty-four-hour, daytime, and nighttime ambulatory and home blood pressure levels were closely associated with the risk of silent cerebrovascular lesions and carotid atherosclerosis (all P<0.05). When home and one of the ambulatory blood pressure values were simultaneously included in the same regression model, each of the ambulatory blood pressure values remained a significant predictor of silent cerebrovascular lesions, whereas home blood pressure lost its predictive value. Of the ambulatory blood pressure values, nighttime blood pressure was the strongest predictor of silent cerebrovascular lesions. The home blood pressure value was more closely associated with the risk of carotid atherosclerosis than any of the ambulatory blood pressure values when home and one of the ambulatory blood pressure values were simultaneously included in the same regression model. The casual/clinic blood pressure value had no significant association with the risk of subclinical cerebrovascular diseases. Although the clinical indications for ambulatory blood pressure monitoring and home blood pressure measurements may overlap, the clinical significance of each method for predicting target organ damage may differ for different target organs.
Azusa Hara; Kazushi Tanaka; Takayoshi Ohkubo; Takeo Kondo; Masahiro Kikuya; Hirohito Metoki; Takanao Hashimoto; Michihiro Satoh; Ryusuke Inoue; Kei Asayama; Taku Obara; Takuo Hirose; Shin-Ichi Izumi; Hiroshi Satoh; Yutaka Imai
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-11-14
Journal Detail:
Title:  Hypertension     Volume:  59     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-16     Completed Date:  2012-02-07     Revised Date:  2012-03-25    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  22-8     Citation Subset:  IM    
Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan.
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MeSH Terms
Asian Continental Ancestry Group / statistics & numerical data*
Blood Pressure
Blood Pressure Monitoring, Ambulatory / statistics & numerical data*
Carotid Artery Diseases / ethnology*
Japan / epidemiology
Logistic Models
Middle Aged
Odds Ratio
Physicians' Offices / statistics & numerical data*
Predictive Value of Tests
Risk Factors
White Coat Hypertension / diagnosis*,  ethnology*
Comment In:
Hypertension. 2012 Mar;59(3):e25; author reply e26   [PMID:  22311898 ]
Hypertension. 2012 Jan;59(1):2-4   [PMID:  22083157 ]

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