Document Detail


Ambient oxygen regulates epithelial metabolism and nitric oxide production in the human nose.
MedLine Citation:
PMID:  12070204     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of ambient O(2) tension on epithelial metabolism and nitric oxide (NO) production (VNO) in the nasal airway were examined in nine healthy volunteers. Nasal VNO, O(2) consumption (VO(2)), and CO(2) production (VCO(2)) were measured during normoxia followed by gradual hypoxia from 21 to 0% O(2) concentration. Nasal VO(2), VCO(2), and respiratory quotient during normoxia were determined to be 1.19 +/- 0.04 ml/min, 1.60 +/- 0.04 ml/min, and 1.35 +/- 0.04, respectively. Hypoxia exposure to the nasal cavity significantly decreased both VCO(2) and VNO [VCO(2): 1.60 +/- 0.04 to 0.96 +/- 0.03 ml/min (P < 0.01), VNO: 530 +/- 15 to 336 +/- 9 nl/min (P < 0.01)]. VNO was reduced commensurately with gradual decline in O(2) tension, and the apparent K(m) value for O(2) was determined to be 23.0 microM. These results indicate that the nasal epithelial cells exchange O(2) and CO(2) with ambient air in the course of their metabolism and that nasal epithelial cells can synthesize NO by using ambient O(2) as a substrate. We conclude that air-borne O(2) diffuses into the epithelium where it may be utilized for either cell metabolism or NO synthesis.
Authors:
Hitoshi Nakano; Hiroshi Ide; Toshiyuki Ogasa; Shinobu Osanai; Masanobu Imada; Satoshi Nonaka; Kenjiro Kikuchi; Jun Iwamoto
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  93     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-06-18     Completed Date:  2002-12-17     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  189-94     Citation Subset:  IM    
Affiliation:
First Department of Medicine, School of Nursing, Asahikawa Medical College, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Carbon Dioxide / metabolism
Epithelium / metabolism
Female
Humans
Kinetics
Male
Middle Aged
Nasal Cavity / physiology
Nitric Oxide / biosynthesis*
Nitric Oxide Synthase / metabolism
Nose / metabolism*
Oxygen / physiology*
Oxygen Consumption / physiology
Chemical
Reg. No./Substance:
10102-43-9/Nitric Oxide; 124-38-9/Carbon Dioxide; 7782-44-7/Oxygen; EC 1.14.13.39/Nitric Oxide Synthase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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