| Ambient air pollution and preterm birth in the environment and pregnancy outcomes study at the University of California, Los Angeles. | |
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MedLine Citation:
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PMID: 17675655 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The authors conducted a case-control survey nested within a birth cohort and collected detailed risk factor information to assess the extent to which residual confounding and exposure misclassification may impact air pollution effect estimates. Using a survey of 2,543 of 6,374 women sampled from a cohort of 58,316 eligible births in 2003 in Los Angeles County, California, the authors estimated with logistic regression and two-phase models the effects of pregnancy period-specific air pollution exposure on the odds of preterm birth. For the first trimester, the odds of preterm birth consistently increased with increasing carbon monoxide exposures and also at high levels of exposure to particulate matter less than or equal to 2.5 microm in diameter (>21.4 microg/m(3)), regardless of type of data (cohort/sample) or covariate adjustment (carbon monoxide exposures of >1.25 ppm increased the odds by 21-25%). Women exposed to carbon monoxide above 0.91 ppm during the last 6 weeks of pregnancy experienced increased odds of preterm birth. Crude and birth certificate covariate-adjusted results for carbon monoxide differed from each other. However, further adjustment for risk factors assessed in the survey did not change effect estimates for short-term pollutant averages appreciably, except for time-activity patterns, which strengthened the observed associations. These results confirm the importance of reducing exposure misclassification when evaluating the effect of traffic-related pollutants that vary spatially. |
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Authors:
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Beate Ritz; Michelle Wilhelm; Katherine J Hoggatt; Jo Kay C Ghosh |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2007-08-04 |
Journal Detail:
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Title: American journal of epidemiology Volume: 166 ISSN: 0002-9262 ISO Abbreviation: Am. J. Epidemiol. Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-10-10 Completed Date: 2007-12-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7910653 Medline TA: Am J Epidemiol Country: United States |
Other Details:
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Languages: eng Pagination: 1045-52 Citation Subset: IM |
Affiliation:
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Department of Epidemiology, School of Public Health, University of California, Los Angeles, CA 90095, USA. britz@ucla.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Air Pollution / adverse effects* Antimetabolites / adverse effects*, analysis Carbon Monoxide / adverse effects*, analysis Case-Control Studies Cohort Studies Female Humans Infant, Newborn Logistic Models Los Angeles / epidemiology Maternal Exposure* Odds Ratio Particle Size Pregnancy Pregnancy Outcome Premature Birth / epidemiology*, etiology* Risk Factors Time Factors Vehicle Emissions / analysis |
| Grant Support | |
ID/Acronym/Agency:
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5P30 ES07048/ES/NIEHS NIH HHS; R01 ES010960-01/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antimetabolites; 0/Vehicle Emissions; 630-08-0/Carbon Monoxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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