Document Detail


Ambient air pollution and low birth weight in Connecticut and Massachusetts.
MedLine Citation:
PMID:  17637932     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Several studies have examined whether air pollution affects birth weight; however results vary and many studies were focused on Southern California or were conducted outside of the United States.
OBJECTIVES: We investigated maternal exposure to particulate matter with aerodynamic diameter < 10, < 2.5 microm (PM(10), PM(2.5)), sulfur dioxide, nitrogen dioxide, and carbon monoxide and birth weight for 358,504 births in Massachusetts and Connecticut from 1999 to 2002.
METHODS: Analysis included logistic models for low birth weight (< 2,500 g) and linear models with birth weight as a continuous variable. Exposure was assigned as the average county-level concentration over gestation and each trimester based on mother's residence. We adjusted for gestational length, prenatal care, type of delivery, child's sex, birth order, weather, year, and mother's race, education, marital status, age, and tobacco use.
RESULTS: An interquartile increase in gestational exposure to NO(2), CO, PM(10), and PM(2.5) lowered birth weight by 8.9 g [95% confidence interval (CI), 7.0-10.8], 16.2 g (95% CI, 12.6-19.7), 8.2 g (95% CI, 5.3-11.1), and 14.7 g (95% CI, 12.3-17.1), respectively. Lower birth weight was associated with exposure in the third trimester for PM(10), the first and third trimesters for CO, the first trimester for NO(2) and SO(2), and the second and third trimesters for PM(2.5). Effect estimates for PM(2.5) were higher for infants of black mothers than those of white mothers.
CONCLUSIONS: Results indicate that exposure to air pollution, even at low levels, may increase risk of low birth weight, particularly for some segments of the population.
Authors:
Michelle L Bell; Keita Ebisu; Kathleen Belanger
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Environmental health perspectives     Volume:  115     ISSN:  0091-6765     ISO Abbreviation:  Environ. Health Perspect.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-07-19     Completed Date:  2007-09-14     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  0330411     Medline TA:  Environ Health Perspect     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1118-24     Citation Subset:  IM    
Affiliation:
School of Forestry and Environmental Studies, Yale University, New Haven, Connecticut 06511, USA. michelle.bell@yale.edu
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MeSH Terms
Descriptor/Qualifier:
Air Pollution*
Carbon Monoxide / toxicity
Connecticut
Female
Humans
Infant, Low Birth Weight*
Infant, Newborn
Massachusetts
Maternal Exposure
Nitrogen Dioxide / toxicity
Particle Size
Pregnancy
Sulfur Dioxide / toxicity
Grant Support
ID/Acronym/Agency:
ES015028/ES/NIEHS NIH HHS; ES07456-07/ES/NIEHS NIH HHS; ES11013/ES/NIEHS NIH HHS; R01 ES007456-07/ES/NIEHS NIH HHS; R01 ES011013-04/ES/NIEHS NIH HHS; R01 ES015028/ES/NIEHS NIH HHS; R01 ES015028-01/ES/NIEHS NIH HHS; R01 ES015028-02/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
10102-44-0/Nitrogen Dioxide; 630-08-0/Carbon Monoxide; 7446-09-5/Sulfur Dioxide
Comments/Corrections
Comment In:
Environ Health Perspect. 2008 Mar;116(3):A106; author reply A106-7   [PMID:  18335071 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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