Document Detail

Ambient air pollution and birth defects in brisbane, australia.
MedLine Citation:
PMID:  19404385     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Birth defects are a major public health concern as they are the leading cause of neonatal and infant mortality. Observational studies have linked environmental pollution to adverse birth outcomes, including congenital anomalies. This study examined potential associations between ambient air pollution and congenital heart defects and cleft lip or palate among births in Brisbane, Australia (1998-2004).
METHODS: Ambient air pollution levels were averaged over weeks 3-8 of pregnancy among 150,308 births. Using a case-control design, we used conditional logistic regression and matched cases to 5 controls. Analyses were conducted using all births, and then births where the mother resided within 6 and 12 kilometers of an ambient air quality monitor.
FINDINGS: When analyzing all births there was no indication that ambient air pollution in Brisbane was associated with a higher risk of cardiac defects. Among births where the mother resided within 6 kilometers of an ambient air quality monitor, a 5 ppb increase in O(3) was associated with an increased risk of pulmonary artery and valve defects (OR 2.96, 95% CI: 1.34, 7.52) while a 0.6 ppb increase in SO(2) was associated with an increased risk of aortic artery and valve defects (OR 10.76, 95% CI: 1.50, 179.8). For oral cleft defects among all births, the only adverse association was between SO(2) and cleft lip with or without cleft palate (OR 1.27, 95% CI: 1.01, 1.62). However, various significant inverse associations were also found between air pollutants and birth defects.
CONCLUSIONS: This study found mixed results and it is difficult to conclude whether ambient air pollution in Brisbane has an adverse association with the birth defects examined. Studies using more detailed estimates of air pollution exposure are needed.
Craig A Hansen; Adrian G Barnett; Bin B Jalaludin; Geoffrey G Morgan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2009-04-30
Journal Detail:
Title:  PloS one     Volume:  4     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2009  
Date Detail:
Created Date:  2009-04-30     Completed Date:  2009-08-07     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e5408     Citation Subset:  IM    
National Center for Environmental Assessment, US Environmental Protection Agency, Durham, North Carolina, United States of America.
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MeSH Terms
Air Pollution / adverse effects*,  analysis
Australia / epidemiology
Carbon Monoxide / analysis
Case-Control Studies
Cleft Lip / etiology
Cleft Palate / etiology
Congenital Abnormalities / epidemiology,  etiology*
Environmental Monitoring
Epidemiological Monitoring
Heart Defects, Congenital / etiology
Infant, Newborn
Logistic Models
Nitrogen Dioxide / analysis
Ozone / analysis
Young Adult
Reg. No./Substance:
10028-15-6/Ozone; 10102-44-0/Nitrogen Dioxide; 630-08-0/Carbon Monoxide

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