Document Detail

Ambient UV, personal sun exposure and risk of multiple primary melanomas.
MedLine Citation:
PMID:  17206532     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Sun exposure is the main cause of melanoma in populations of European origin. No previous study has examined the effect of sun exposure on risk of multiple primary melanomas compared with people who have one melanoma.
METHODS: We identified and enrolled 2,023 people with a first primary melanoma (controls) and 1,125 with multiple primary melanomas (cases) in seven centers in four countries, recorded their residential history to assign ambient UV and interviewed them about their sun exposure.
RESULTS: Risk of multiple primary melanomas increased significantly (P<0.05) to OR=2.10 for the highest exposure quarter of ambient UV irradiance at birth and 10 years of age, to OR=1.38 for lifetime recreational sun exposure, to OR=1.85 for beach and waterside activities, to OR=1.57 for vacations in a sunnier climate, to OR=1.50 for sunburns. Occupational sun exposure did not increase risk (OR=1.03 for highest exposure). Recreational exposure at any age increased risk and appeared to add to risk from ambient UV in early life.
CONCLUSIONS: People who have had a melanoma can expect to reduce their risk of a further melanoma by reducing recreational sun exposure whatever their age. The same is probably true for a person who has never had a melanoma.
Anne Kricker; Bruce K Armstrong; Chris Goumas; Melisa Litchfield; Colin B Begg; Amanda J Hummer; Loraine D Marrett; Beth Theis; Robert C Millikan; Nancy Thomas; Hoda Anton Culver; Richard P Gallagher; Terence Dwyer; Timothy R Rebbeck; Peter A Kanetsky; Klaus Busam; Lynn From; Urvi Mujumdar; Roberto Zanetti; Marianne Berwick;
Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2007-01-06
Journal Detail:
Title:  Cancer causes & control : CCC     Volume:  18     ISSN:  0957-5243     ISO Abbreviation:  Cancer Causes Control     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-05     Completed Date:  2007-05-01     Revised Date:  2014-10-23    
Medline Journal Info:
Nlm Unique ID:  9100846     Medline TA:  Cancer Causes Control     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  295-304     Citation Subset:  IM    
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MeSH Terms
Environmental Exposure
Melanoma / etiology*
Middle Aged
Neoplasms, Multiple Primary / etiology*
Neoplasms, Radiation-Induced*
Occupational Exposure
Odds Ratio
Radiation Dosage
Risk Factors
Risk Reduction Behavior
Skin Neoplasms / etiology*
Sunlight / adverse effects*
Ultraviolet Rays / adverse effects*
Grant Support
CA098438/CA/NCI NIH HHS; CA16086/CA/NCI NIH HHS; CA46592/CA/NCI NIH HHS; CA83180/CA/NCI NIH HHS; K07 CA102096/CA/NCI NIH HHS; K07 CA102096-03/CA/NCI NIH HHS; P30 CA118100/CA/NCI NIH HHS; R01 CA112243/CA/NCI NIH HHS; R01 CA112243-04/CA/NCI NIH HHS; R01 CA112524/CA/NCI NIH HHS; U01 CA083180/CA/NCI NIH HHS

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