Document Detail

Ambient particulate matter and the response to orthostatic challenge in the elderly: the Maintenance of Balance, Independent Living, Intellect, and Zest in the Elderly (MOBILIZE) of Boston study.
MedLine Citation:
PMID:  22275528     Owner:  NLM     Status:  MEDLINE    
Short-term elevations in ambient fine particulate matter (PM(2.5)) may increase resting systolic (SBP) and diastolic (DBP) blood pressures, but whether PM(2.5) alters hemodynamic responses to orthostatic challenge has not been studied in detail. We repeatedly measured SBP and DBP during supine rest and 1 and 3 minutes after standing among 747 elderly (aged 78.3±5.3 years, mean±SD) participants from a prospective cohort study. We used linear mixed models to assess the association between change in SBP (ΔSBP=standing SBP-supine SBP) and DBP (ΔDBP) on standing and mean PM(2.5) levels over the preceding 1 to 28 days, adjusting for meteorologic covariates, temporal trends, and medical history. We observed a 1.4-mm Hg (95% CI: 0.0-2.8 mm Hg; P=0.046) higher ΔSBP and a 0.7-mm Hg (95% CI: 0.0-1.4 mm Hg; P=0.053) higher ΔDBP at 1 minute of standing per interquartile range increase (3.8 μg/m(3)) in mean PM(2.5) levels in the past 7 days. ΔSBP and ΔDBP measured 3 minutes after standing were not associated with PM(2.5). Resting DBP (but not SBP or pulse pressure) was positively associated with PM(2.5) at longer averaging periods. Responses were more strongly associated with black carbon than sulfate levels. These associations did not differ significantly according to hypertension status, obesity, diabetes mellitus, or sex. These results suggest that ambient particles can increase resting DBP and exaggerate blood pressure responses to postural changes in elderly people. Increased vasoreactivity during posture change may be responsible, in part, for the adverse effect of ambient particles on cardiovascular health.
Gregory A Wellenius; Charlotte S Wilhelm-Benartzi; Elissa H Wilker; Brent A Coull; Helen H Suh; Petros Koutrakis; Lewis A Lipsitz
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-01-23
Journal Detail:
Title:  Hypertension     Volume:  59     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-20     Completed Date:  2012-04-17     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  558-63     Citation Subset:  IM    
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MeSH Terms
Aging / drug effects*
Autonomic Nervous System / drug effects,  physiopathology*
Follow-Up Studies
Hypertension / physiopathology*
Hypotension, Orthostatic / physiopathology*
Independent Living*
Particulate Matter / pharmacology*
Postural Balance / physiology*
Prospective Studies
Grant Support
AG004390/AG/NIA NIH HHS; AG25037/AG/NIA NIH HHS; ES000002/ES/NIEHS NIH HHS; ES009825/ES/NIEHS NIH HHS; ES015774/ES/NIEHS NIH HHS; P01 AG004390/AG/NIA NIH HHS; P01 AG004390-25/AG/NIA NIH HHS; P01 ES009825/ES/NIEHS NIH HHS; P01 ES009825-10/ES/NIEHS NIH HHS; P30 ES000002/ES/NIEHS NIH HHS; P30 ES000002-49/ES/NIEHS NIH HHS; R00 ES015774/ES/NIEHS NIH HHS; R00 ES015774-05/ES/NIEHS NIH HHS; R37 AG025037/AG/NIA NIH HHS; R37 AG025037-07/AG/NIA NIH HHS; T32 HL007374-28/HL/NHLBI NIH HHS; T32-HL007374/HL/NHLBI NIH HHS
Reg. No./Substance:
0/Particulate Matter

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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