Document Detail

Ambient air pollution and the risk of stillbirth.
MedLine Citation:
PMID:  22811493     Owner:  NLM     Status:  MEDLINE    
The purpose of the present study was to examine the risk of stillbirth associated with ambient air pollution during pregnancy. Using live birth and fetal death data from New Jersey from 1998 to 2004, the authors assigned daily concentrations of air pollution to each birth or fetal death. Generalized estimating equation models were used to estimate the relative odds of stillbirth associated with interquartile range increases in mean air pollutant concentrations in the first, second, and third trimesters and throughout the entire pregnancy. The relative odds of stillbirth were significantly increased with each 10-ppb increase in mean nitrogen dioxide concentration in the first trimester (odds ratio (OR) = 1.16, 95% confidence interval (CI): 1.03, 1.31), each 3-ppb increase in mean sulfur dioxide concentration in the first (OR = 1.13, 95% CI: 1.01, 1.28) and third (OR = 1.26, 95% CI: 1.03, 1.37) trimesters, and each 0.4-ppm increase in mean carbon monoxide concentration in the second (OR = 1.14, 95% CI: 1.01, 1.28) and third (OR = 1.14, 95% CI: 1.06, 1.24) trimesters. Although ambient air pollution during pregnancy appeared to increase the relative odds of stillbirth, further studies are needed to confirm these findings and examine mechanistic explanations.
Ambarina S Faiz; George G Rhoads; Kitaw Demissie; Lakota Kruse; Yong Lin; David Q Rich
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-07-18
Journal Detail:
Title:  American journal of epidemiology     Volume:  176     ISSN:  1476-6256     ISO Abbreviation:  Am. J. Epidemiol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-10     Completed Date:  2012-10-15     Revised Date:  2013-08-18    
Medline Journal Info:
Nlm Unique ID:  7910653     Medline TA:  Am J Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  308-16     Citation Subset:  IM    
Department of Medicine, Robert Wood Johnson Medical School, University of Melbourne and Dentistry of New Jersey, New Brunswick, NJ 08903, USA.
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MeSH Terms
Air Pollutants / adverse effects*,  analysis
Air Pollution / adverse effects*,  analysis,  statistics & numerical data
Carbon Monoxide / adverse effects,  analysis
Cohort Studies
Maternal Exposure / adverse effects*,  statistics & numerical data
Middle Aged
Models, Statistical
New Jersey / epidemiology
Nitrogen Dioxide / adverse effects,  analysis
Odds Ratio
Particulate Matter / adverse effects,  analysis
Pregnancy Trimesters
Risk Factors
Stillbirth* / epidemiology
Sulfur Dioxide / adverse effects,  analysis
Grant Support
Reg. No./Substance:
0/Air Pollutants; 0/Particulate Matter; 10102-44-0/Nitrogen Dioxide; 630-08-0/Carbon Monoxide; 7446-09-5/Sulfur Dioxide

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