Document Detail


Amazing chloride channels: an overview.
MedLine Citation:
PMID:  12558550     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This review describes molecular and functional properties of the following Cl- channels: the ClC family of voltage-dependent Cl- channels, the cAMP-activated transmembrane conductance regulator (CFTR), Ca2+ activated Cl- channels (CaCC) and volume-regulated anion channels (VRAC). If structural data are available, their relationship with the function of Cl- channels will be discussed. We also describe shortly some recently discovered channels, including high conductance Cl- channels and the family of bestrophins. We illustrate the growing physiological importance of these channels in the plasma membrane and in intracellular membranes, including their involvement in transepithelial transport, pH regulation of intracellular organelles, regulation of excitability and volume regulation. Finally, we discuss the role of Cl- channels in various diseases and describe the pathological phenotypes observed in knockout mice models.
Authors:
B Nilius; G Droogmans
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Acta physiologica Scandinavica     Volume:  177     ISSN:  0001-6772     ISO Abbreviation:  Acta Physiol. Scand.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-01-31     Completed Date:  2003-04-28     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  0370362     Medline TA:  Acta Physiol Scand     Country:  England    
Other Details:
Languages:  eng     Pagination:  119-47     Citation Subset:  IM    
Affiliation:
KU Leuven, Laboratorium voor Fysiologie, Campus Gasthuisberg, Leuven, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anions / metabolism
Biological Transport
Calcium / physiology
Cell Membrane / physiology
Chloride Channels / physiology*
Cyclic AMP / physiology
Cystic Fibrosis Transmembrane Conductance Regulator / physiology
Disease Models, Animal
Electric Conductivity
Hydrogen-Ion Concentration
Intracellular Membranes / physiology
Kinetics
Mice
Mice, Knockout
Models, Biological
Organelles / physiology
Phenotype
Phosphorylation
Proteins / metabolism
Chemical
Reg. No./Substance:
0/Anions; 0/Chloride Channels; 0/Proteins; 126880-72-6/Cystic Fibrosis Transmembrane Conductance Regulator; 60-92-4/Cyclic AMP; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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