Document Detail


Amanita phalloides poisoning and treatment with silibinin in the Australian Capital Territory and New South Wales.
MedLine Citation:
PMID:  23330770     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To report the frequency and clinical outcomes of Amanita phalloides poisoning in the Australian Capital Territory and New South Wales, and the treatments used (including silibinin).
DESIGN, SETTING AND PATIENTS: Retrospective case series of patients admitted to public hospitals in Canberra and Sydney for suspected A. phalloides poisoning between 1999 and 2012 (identified from hospital records and calls to the New South Wales Poisons Information Centre).
MAIN OUTCOME MEASURES: Frequency of poisoning and the clinical outcomes.
RESULTS: Twelve patients presented with a history suggesting A. phalloides poisoning, 10 with probable poisoning and two with possible poisoning. Eight of those with probable poisoning developed significant hepatotoxicity and four died. Silibinin was administered to nine of those with probable poisoning (the other presented before 2005). Maintaining silibinin supply became a challenge during two clusters of poisoning. Eight of the patients with probable poisoning were not long-term residents of the ACT, and six were immigrants from Asia.
CONCLUSIONS: The mortality rate due to A. phalloides poisoning in this case series was high despite treatment according to current standards, including use of silibinin, and the frequency of hepatotoxicity was more than double that for the previous decade. Ongoing public health campaigns are required.
Authors:
Darren M Roberts; Michael J Hall; Morna M Falkland; Simone I Strasser; Nick A Buckley
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Medical journal of Australia     Volume:  198     ISSN:  1326-5377     ISO Abbreviation:  Med. J. Aust.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-21     Completed Date:  2013-04-05     Revised Date:  2013-12-31    
Medline Journal Info:
Nlm Unique ID:  0400714     Medline TA:  Med J Aust     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  43-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Amanita
Antidotes / supply & distribution,  therapeutic use*
Australian Capital Territory / epidemiology
Child
Child, Preschool
Female
Health Promotion
Humans
Male
Middle Aged
Mushroom Poisoning / drug therapy,  epidemiology*,  mortality
New South Wales / epidemiology
Poison Control Centers / statistics & numerical data
Retrospective Studies
Silymarin / supply & distribution,  therapeutic use*
Young Adult
Chemical
Reg. No./Substance:
0/Antidotes; 0/Silymarin; 4RKY41TBTF/silybin
Comments/Corrections
Comment In:
Med J Aust. 2013 Nov 18;199(10):659-60   [PMID:  24237090 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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