| Alzheimer's and seizures: interleukin-18, indoleamine 2,3-dioxygenase and quinolinic Acid. | |
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MedLine Citation:
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PMID: 22084597 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Emergent seizures are common in Alzheimer's disease (AD), although the mechanisms mediating this are unknown. It is proposed that stress induced interleukin-18 (IL-18), via interferon-gamma (IFNy) and independently, increases indoleamine 2,3-dioxygenase (IDO) and subsequent quinolinic acid (QA) in microglia. QA increases seizures and concurrently contributes to neuronal loss via excitotoxicity. The ApoE4 allele interacts with IL-18 polymorphisms to increase the risk of AD, and seems likely to potentiate the emergence of seizures. Concurrent changes in IDO and the kynurenine pathways at the blood-brain-barrier (BBB) have implications for treatment, including in the efficacy of different anti-hypertensives. Melatonin is proposed to inhibit these overlapping excitotoxic and neurodegenerative processes, and would be a useful adjunctive treatment. |
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Authors:
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G Anderson; Jo Ojala |
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Publication Detail:
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Type: Journal Article Date: 2010-10-15 |
Journal Detail:
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Title: International journal of tryptophan research : IJTR Volume: 3 ISSN: 1178-6469 ISO Abbreviation: Int J Tryptophan Res Publication Date: 2010 |
Date Detail:
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Created Date: 2011-11-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101513378 Medline TA: Int J Tryptophan Res Country: New Zealand |
Other Details:
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Languages: eng Pagination: 169-73 Citation Subset: - |
Affiliation:
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CRC, Rm 1/2, 1229 Dumbarton Road, Glasgow, Scotland, U.K. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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