| Alzheimer's disease: a pathogenic role for aluminosilicate-induced phagocytic free radicals. | |
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MedLine Citation:
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PMID: 2551793 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The occurrence of aluminosilicate deposits within the cerebral plaques in Alzheimer's senile dementia sufferers has prompted further consideration of the possible role of such materials in the aetiology and pathogenesis of the disease. We have monitored the ability of various natural and synthetic model aluminosilicate particulates of differing morphological and chemical composition to stimulate the generation of phagocyte-derived free radical reactive oxygen metabolites (ROM) using an in vitro chemiluminescent technique on purified human blood-derived polymorphonuclear leukocytes (PMN). The results indicate that an enhanced chemiluminescent response is produced by calcium-bearing fibriform particulates. It is proposed that an analogous in vivo particle-induced and phagocyte-mediated oxidative stress could provide a potential pathogenic mechanism in the development of Alzheimer's disease. |
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Authors:
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P H Evans; J Klinowski; E Yano; N Urano |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Free radical research communications Volume: 6 ISSN: 8755-0199 ISO Abbreviation: Free Radic. Res. Commun. Publication Date: 1989 |
Date Detail:
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Created Date: 1989-11-21 Completed Date: 1989-11-21 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8709453 Medline TA: Free Radic Res Commun Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 317-21 Citation Subset: IM |
Affiliation:
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M.R.C. Dunn Nutrition Unit, Cambridge, England. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aluminum Silicates
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toxicity* Alzheimer Disease / blood*, etiology Free Radicals Humans Kinetics Luminescent Measurements Neutrophils / drug effects* Phagocytosis / drug effects* Zeolites |
| Chemical | |
Reg. No./Substance:
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0/Aluminum Silicates; 0/Free Radicals; 1318-02-1/Zeolites; 1327-36-2/aluminosilicate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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