| Alzheimer's disease markers, hypertension, and gray matter damage in normal elderly. | |
| | |
MedLine Citation:
|
PMID: 21530003 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
It is not well known whether Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarkers are associated with brain damage in cognitively normal elderly. The combined influence of CSF biomarkers and hypertension (HTN) on the gray matter (GM) is also not well described. One hundred fifteen cognitively healthy subjects (mean age 62.6 ± 9.5%, 62% women) received clinical assessment, a high resolution magnetic resonance imaging (MRI), and a lumbar puncture. The CSF levels of total tau (t-tau), hyperphosphorylated tau (p-tau(231)), amyloid beta (Aβ42/Aβ40), p-tau(231)/Aβ42, and t-tau/Aβ42 were dichotomized as "high" and "low" based on accepted cut off values. Statistical parametric mapping was used to examine MRI scans for regional GM density, studied as a function of the CSF markers, HTN, and combination of both. Global and medial temporal lobe (MTL) GM was also assessed. Voxel based morphometry revealed that higher t-tau was associated with lower GM density in the precunei. Subjects with higher p-tau(231) and p-tau(231)/Aβ42 had less GM in temporal lobes. Low Aβ42/Aβ40 was related to less GM in the thalami, caudate, and midbrain. Subjects with hypertension showed more GM atrophy in the cerebellum, occipital, and frontal regions. Simultaneous presence of elevated CSF AD biomarkers and HTN was associated with more GM atrophy than either marker individually, but no interaction effects were identified. In conclusion, in normal elderly CSF tau markers were associated predominantly with lower GM estimates in structures typically affected early in the AD process. In this presymptomatic stage when no cognitive impairment is present, AD biomarkers and HTN have additive effects on gray matter damage. |
| | |
Authors:
|
Lidia Glodzik; Lisa Mosconi; Wai Tsui; Susan de Santi; Raymond Zinkowski; Elizabeth Pirraglia; Kenneth E Rich; Pauline McHugh; Yi Li; Schantel Williams; Fahad Ali; Henrik Zetterberg; Kaj Blennow; Pankaj Mehta; Mony J de Leon |
Related Documents
:
|
16049563 - Diagnostic capabilities of i-131, ti-201, and tc-99m-mibi scintigraphy for metastatic d... 16412863 - Characterization of radiofrequency ablation lesions with gadolinium-enhanced cardiovasc... 2617413 - The infratemporal fossa: a trial clarification. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-4-27 |
Journal Detail:
|
Title: Neurobiology of aging Volume: - ISSN: 1558-1497 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-5-2 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8100437 Medline TA: Neurobiol Aging Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
|
New York University School of Medicine, New York, NY, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Sensory memory during physiological aging indexed by mismatch negativity (MMN).
Next Document: Descriptive study of hepatocellular carcinoma in noncirrhotic liver.