Document Detail


Alzheimer's disease in a dish: promises and challenges of human stem cell models.
MedLine Citation:
PMID:  22865875     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Human pluripotent stem cells can differentiate into disease-relevant cell types, which capture the unique genome of an individual patient and provide insight into pathological mechanisms of human disease. Recently, human stem cell models for Alzheimer's disease (AD), the most common neurodegenerative dementia, have been described. Stem cell-derived neurons from patients with familial and sporadic AD and Down's syndrome recapitulate human disease phenotypes such as amyloid β peptide production, hyperphosphorylation of tau protein and endosomal abnormalities. Treatment of human neurons with small molecules can modulate these phenotypes, demonstrating the utility of this system for drug development and screening. This review will highlight the current AD stem cell models and discuss the remaining challenges and potential future directions of this field.
Authors:
Jessica E Young; Lawrence S B Goldstein
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-08-02
Journal Detail:
Title:  Human molecular genetics     Volume:  21     ISSN:  1460-2083     ISO Abbreviation:  Hum. Mol. Genet.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-28     Completed Date:  2013-04-05     Revised Date:  2013-10-17    
Medline Journal Info:
Nlm Unique ID:  9208958     Medline TA:  Hum Mol Genet     Country:  England    
Other Details:
Languages:  eng     Pagination:  R82-9     Citation Subset:  IM    
Affiliation:
Department of Cellular and Molecular Medicine, USCD School of Medicine,9500 Gilman Drive, La Jolla, CA 92093, USA.
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MeSH Terms
Descriptor/Qualifier:
Alzheimer Disease* / genetics,  metabolism,  pathology
Amyloid beta-Peptides / metabolism
Amyloid beta-Protein Precursor / genetics,  metabolism
Cell Differentiation
Down Syndrome / metabolism
Humans
Induced Pluripotent Stem Cells* / cytology,  physiology
Neurons* / metabolism
Phenotype
Stem Cell Research
tau Proteins / genetics,  metabolism
Grant Support
ID/Acronym/Agency:
R01AG032180/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/APP protein, human; 0/Amyloid beta-Peptides; 0/Amyloid beta-Protein Precursor; 0/tau Proteins
Comments/Corrections

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