| Alzheimer's disease in a dish: promises and challenges of human stem cell models. | |
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MedLine Citation:
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PMID: 22865875 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Human pluripotent stem cells can differentiate into disease-relevant cell types, which capture the unique genome of an individual patient and provide insight into pathological mechanisms of human disease. Recently, human stem cell models for Alzheimer's disease (AD), the most common neurodegenerative dementia, have been described. Stem cell-derived neurons from patients with familial and sporadic AD and Down's syndrome recapitulate human disease phenotypes such as amyloid β peptide production, hyperphosphorylation of tau protein and endosomal abnormalities. Treatment of human neurons with small molecules can modulate these phenotypes, demonstrating the utility of this system for drug development and screening. This review will highlight the current AD stem cell models and discuss the remaining challenges and potential future directions of this field. |
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Authors:
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Jessica E Young; Lawrence S B Goldstein |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2012-08-02 |
Journal Detail:
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Title: Human molecular genetics Volume: 21 ISSN: 1460-2083 ISO Abbreviation: Hum. Mol. Genet. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-09-28 Completed Date: 2013-04-05 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 9208958 Medline TA: Hum Mol Genet Country: England |
Other Details:
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Languages: eng Pagination: R82-9 Citation Subset: IM |
Affiliation:
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Department of Cellular and Molecular Medicine, USCD School of Medicine,9500 Gilman Drive, La Jolla, CA 92093, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alzheimer Disease*
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genetics,
metabolism,
pathology Amyloid beta-Peptides / metabolism Amyloid beta-Protein Precursor / genetics, metabolism Cell Differentiation Down Syndrome / metabolism Humans Induced Pluripotent Stem Cells* / cytology, physiology Neurons* / metabolism Phenotype Stem Cell Research tau Proteins / genetics, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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R01AG032180/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/APP protein, human; 0/Amyloid beta-Peptides; 0/Amyloid beta-Protein Precursor; 0/tau Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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