Document Detail


Alzheimer's disease and glaucoma: mechanistic similarities and differences.
MedLine Citation:
PMID:  23733125     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Alzheimer's disease (AD) is the most common form of dementia. Intraneuronal neurofibrillary tangles, extracellular Aβ amyloid deposits in the form of amyloid plaques and cerebral amyloid angiopathy, and synaptic and neuronal loss co-exist in the brain parenchyma, with the limbic areas being the most severely affected. The classic clinical findings are personality changes, progressive cognitive dysfunction, and loss of ability to perform activities of daily living. Visual impairment is common and appears related to disease severity, suggesting that visual testing may provide a method of screening and tracking AD changes. Although still not fully understood, research and clinical findings point to a possible common causal relationship between AD and glaucoma. These two chronic neurodegenerative disorders share biological and mechanistic features, among them (1) a strong age-related incidence, (2) retinal ganglion cell degeneration, and (3) extracellular fibrillar deposits in exfoliation syndrome, the most common recognizable cause of glaucoma, suggesting that both diseases may originate from similar misfolding mechanisms. A presentation of common pathogenetic pathways associated with these disorders, including cell death mechanisms, reactive oxygen species (ROS) production, mitochondrial dysfunction and vascular abnormalities, will serve as an initiation point for further exploration.
Authors:
Jorge A Ghiso; Ivo Doudevski; Robert Ritch; Agueda A Rostagno
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Journal of glaucoma     Volume:  22 Suppl 5     ISSN:  1536-481X     ISO Abbreviation:  J. Glaucoma     Publication Date:    2013 Jun-Jul
Date Detail:
Created Date:  2013-06-04     Completed Date:  2014-02-25     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  9300903     Medline TA:  J Glaucoma     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S36-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Alzheimer Disease* / complications,  diagnosis,  metabolism
Disease Progression
Glaucoma* / complications,  diagnosis,  metabolism,  physiopathology
Humans
Oxidative Stress*
Retinal Ganglion Cells / metabolism,  pathology
Grant Support
ID/Acronym/Agency:
AG030539/AG/NIA NIH HHS; R01 AG030539/AG/NIA NIH HHS; R21 EY019129/EY/NEI NIH HHS
Comments/Corrections
Erratum In:
J Glaucoma. 2013 Sep;22(7):597-8
Note: Doudevski, Ivo [added]; Ritch, Robert [added]; Rostagno, Agueda A [added]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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