| Alzheimer's disease: a disorder of cortical cholinergic innervation. | |
| | |
MedLine Citation:
|
PMID: 6338589 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Great emphasis is being placed on identification of neurotransmitter systems involved in the symptomatic manifestations of neurological and psychiatric disorders. In the case of Alzheimer's disease, which now seems to be one of the most common causes of mental deterioration in the elderly, compelling evidence has been developed that acetylcholine-releasing neurons, whose cell bodies lie in the basal forebrain, selectively degenerate. These cholinergic neurons provide widespread innervation of the cerebral cortex and related structures and appear to play an important role in cognitive functions, especially memory. These advances reflect a close interaction between experimental and clinical neuroscientists in which information derived from basic neurobiology is rapidly utilized to analyze disorders of the human brain. |
| | |
Authors:
|
J T Coyle; D L Price; M R DeLong |
Related Documents
:
|
2008399 - Managing dysphagia. special problems in patients with neurologic disease. 19569889 - National institute of neurological disorders and stroke support for brain-machine inter... 16120409 - The neurological presentations of childhood and adult mitochondrial disease: establishe... 15935199 - Sleep in patients with neurologic and psychiatric disorders. 942289 - Neurologic soft signs in schizophrenia and character disorders. organicity in schizophr... 17395129 - Challenges in the design and conduct of therapeutic trials in channel disorders. 17942279 - What is specific to suicide in schizophrenia disorder? demographic, clinical and behavi... 10557169 - Terminology and diagnostic classification of temporomandibular joint dysfunction syndro... 18442139 - Neural control of the gastrointestinal tract: implications for parkinson disease. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
|
Title: Science (New York, N.Y.) Volume: 219 ISSN: 0036-8075 ISO Abbreviation: Science Publication Date: 1983 Mar |
Date Detail:
|
Created Date: 1983-04-07 Completed Date: 1983-04-07 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0404511 Medline TA: Science Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1184-90 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Alzheimer Disease
/
physiopathology* Behavior Brain / physiopathology* Brain Mapping Cerebral Cortex / physiopathology Cholinergic Fibers / physiopathology* Cognition Dementia / physiopathology* Hippocampus / physiopathology Humans |
| Grant Support | |
ID/Acronym/Agency:
|
NS 07179/NS/NINDS NIH HHS; NS 10580/NS/NINDS NIH HHS; NS 15721/NS/NINDS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Systemic chronic juvenile arthritis (Still's disease) in adults. Review of the literature
Next Document: Deficiency of a kidney metalloproteinase activity in inbred mouse strains.