Document Detail


Alzheimer's disease, Kuf's disease, tellurium and selenium.
MedLine Citation:
PMID:  8869917     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The possible role of the abnormal trace element tellurium in the pathogenesis of Alzheimer's disease is examined. Tellurium has been reported to produce cognitive impairment and cerebral lipofuscinosis in rats-changes akin to those seen in Kuf's disease, a condition which shares certain clinical and neuropathological features with Alzheimer's disease. Tellurium can damage mitochondria; defects in mitochondrial energy metabolism may be relevant to the pathogenesis of neurodegenerative disease. The deficiency of selenium, which may act physiologically as an antagonist of tellurium, in the Alzheimer's disease brain would also be in keeping with the hypothesis of tellurium toxicity as a factor in the pathogenesis of Alzheimer's disease.
Authors:
A J Larner
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Medical hypotheses     Volume:  47     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  1996 Aug 
Date Detail:
Created Date:  1997-01-22     Completed Date:  1997-01-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  73-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Alzheimer Disease / etiology*,  physiopathology,  psychology
Animals
Energy Metabolism
Humans
Mitochondria / drug effects,  metabolism,  pathology
Models, Biological
Neuronal Ceroid-Lipofuscinoses / etiology*,  physiopathology,  psychology
Rats
Selenium / deficiency*
Tellurium / toxicity*
Chemical
Reg. No./Substance:
13494-80-9/Tellurium; 7782-49-2/Selenium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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