Document Detail

Alzheimer's, angiotensin IV and an aminopeptidase.
MedLine Citation:
PMID:  15187413     Owner:  NLM     Status:  MEDLINE    
The angiotensin AT(4) receptor was originally defined as the specific, high affinity binding site for the hexapeptide angiotensin IV (Ang IV). Subsequently, the peptide LVV-hemorphin 7 was also demonstrated to be a bioactive ligand of the AT(4) receptor. Central administration of Ang IV or LVV-hemorphin 7 (LVV-H7) markedly enhances learning and memory in normal rodents and reverse memory deficits observed in animal models of amnesia. The high affinity binding site has a broad distribution in the brain including areas such as the hippocampus that are involved in memory processing. The high affinity Ang IV binding site (AT(4) receptor) has been identified as the transmembrane enzyme, insulin-regulated membrane aminopeptidase (IRAP). Insulin-regulated aminopeptidase is a type II integral membrane spanning protein belonging to the M1 family of aminopeptidases and in insulin-responsive cells colocalizes with GLUT4 in specific intra-cellular vesicles. Both Ang IV and LVV-H7 are competitive inhibitors of IRAP catalytic activity and are not substrates of the enzyme.
Anthony Lloyd Albiston; Ruani Fernando; Siying Ye; Grantley Ross Peck; Siew Yeen Chai
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Biological & pharmaceutical bulletin     Volume:  27     ISSN:  0918-6158     ISO Abbreviation:  Biol. Pharm. Bull.     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-06-09     Completed Date:  2005-01-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9311984     Medline TA:  Biol Pharm Bull     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  765-7     Citation Subset:  IM    
Howard Florey Institute, The University of Melbourne, Parkville, Victoria, Australia.
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MeSH Terms
Alzheimer Disease / enzymology*,  metabolism
Aminopeptidases / metabolism*
Angiotensin II / analogs & derivatives*,  metabolism,  physiology*
Binding Sites / physiology
Reg. No./Substance:
11128-99-7/Angiotensin II; 23025-68-5/angiotensin II, des-Asp(1)-des-Arg(2)-Ile(5)-; EC 3.4.11.-/Aminopeptidases

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