Document Detail


Alzheimer's disease: brain desmosterol levels.
MedLine Citation:
PMID:  23042211     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Desmosterol is a C27 sterol intermediate in cholesterol synthesis generated during the metabolic pathway that transforms lanosterol into cholesterol. It has become of particular interest in the pathogenesis of Alzheimer's disease (AD) because of the report that the activity of the gene coding for the enzyme DHCR24, which metabolizes desmosterol to cholesterol, is selectively reduced in the affected areas of the brain. Any change in the pattern of C27 sterol intermediates in cholesterol synthesis merits investigation with respect to the pathogenesis of AD, since neurosteroids such as progesterone can modulate the tissue levels. We therefore analyzed the C27 sterol composition using a metabolomics approach that preserves the proportion of the different sterol intermediates. In AD, the proportion of desmosterol was found to be less than that of age-matched controls. The findings do not directly support the focus on Seladin-1, although they could reflect different stages of a slowly progressive disease.
Authors:
Thomas Wisniewski; Kia Newman; Norman B Javitt
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of Alzheimer's disease : JAD     Volume:  33     ISSN:  1875-8908     ISO Abbreviation:  J. Alzheimers Dis.     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-14     Completed Date:  2013-06-25     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  9814863     Medline TA:  J Alzheimers Dis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  881-8     Citation Subset:  IM    
Affiliation:
Department of Neurology, School of Medicine, New York University, New York, NY 10016, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Alzheimer Disease / pathology*
Brain / metabolism*
Desmosterol / chemistry,  metabolism*
Female
Humans
Male
Middle Aged
Nerve Tissue Proteins / genetics,  metabolism
Grant Support
ID/Acronym/Agency:
AG08051/AG/NIA NIH HHS; AG20245/AG/NIA NIH HHS; P30 AG008051/AG/NIA NIH HHS; R01 AG020245/AG/NIA NIH HHS; R01 NS073502/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Nerve Tissue Proteins; 313-04-2/Desmosterol
Comments/Corrections

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