Document Detail


Alzheimer pathology of patients carrying apolipoprotein E epsilon 4 allele.
MedLine Citation:
PMID:  8544899     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A recent report suggested that brains of Alzheimer patients homozygous for APOE epsilon 4 show increased amyloid pathology compared to APOE epsilon 3 homozygotes. We studied APOE allele frequencies in 73 AD patients and 38 controls. We also investigated relation of APOE genotypes to beta/A4 immunopositive plaques, cerebrovascular beta/A4 deposition, neurons expressing paired helical filaments (PHFs), and synaptophysin-like immunopositivity in 22 neuropathologically verified AD patients. We also correlated APOE genotypes of definite AD patients to beta/A4 immunoreactivity in dermal vessel walls detected in lifetime skin biopsy samples. APOE allele epsilon 4 frequency was increased in AD compared to nondemented controls (0.37 vs. 0.11; p = 0.006). The number of beta/A4 immunoreactive plaques, PHFs-containing neurons, the degree of cerebrovascular beta/A4 deposition or synaptophysin-like immunoreactivity did not differ significantly in AD patients with or without epsilon 4. beta/A4 deposition in dermal vessel walls was more frequent in definite AD patients with epsilon 4 (43%) than in patients without epsilon 4 (22%). However, the difference did not reach the statistical significance.
Authors:
O Heinonen; M Lehtovirta; H Soininen; S Helisalmi; A Mannermaa; H Sorvari; O Kosunen; L Paljärvi; M Ryynänen; P J Riekkinen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurobiology of aging     Volume:  16     ISSN:  0197-4580     ISO Abbreviation:  Neurobiol. Aging     Publication Date:    1995 Jul-Aug
Date Detail:
Created Date:  1996-02-14     Completed Date:  1996-02-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8100437     Medline TA:  Neurobiol Aging     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  505-13     Citation Subset:  IM    
Affiliation:
Department of Neurology, Kuopio University Hospital, University of Kuopio, Finland.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Alleles
Alzheimer Disease / genetics*,  pathology
Amyloid beta-Protein / metabolism
Analysis of Variance
Apolipoproteins E / genetics*
Blood Vessels / metabolism
Brain / blood supply,  metabolism,  pathology
Chi-Square Distribution
Female
Gene Frequency
Genotype
Humans
Male
Neurofibrillary Tangles / metabolism
Neurons / metabolism
Skin / blood supply
Synapses
Synaptophysin / metabolism
tau Proteins / metabolism
Chemical
Reg. No./Substance:
0/Amyloid beta-Protein; 0/Apolipoproteins E; 0/Synaptophysin; 0/tau Proteins

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