Document Detail


Alzheimer disease with amygdala Lewy bodies: a distinct form of alpha-synucleinopathy.
MedLine Citation:
PMID:  16825955     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lewy bodies (LBs) are alpha-synuclein-immunoreactive neuronal inclusions with a predilection for specific cortical and subcortical regions, including the amygdala. In this study, the presence of LBs was assessed in 347 cases of Alzheimer disease (AD). In 87 cases, LB pathology was diagnostic of brainstem (n=3), transitional (n=32), or diffuse (n=52) Lewy body disease (LBD). The remaining 260 cases of AD were screened for amygdala LBs (AD/ALB) and 62 (24%) cases were found. If AD/LBD cases are included, LBs were detected in 149 (43%) cases of AD. The presence alpha-synuclein pathology was assessed in multiple brain regions of the 62 cases of AD/ALB and 57 randomly selected cases of AD, and only sparse alpha-synuclein pathology was detected in both. The burden of alpha-synuclein pathology in brainstem nuclei, amygdala, and neocortex was significant lower in AD/ALB than in AD/LBD. In comparison to AD/LBD, AD/ALB did not differ in age at death, disease duration, male-to-female ratio, brain weight, Braak neurofibrillary tangle stage, average senile plaque density, or apolipoprotein E epsilon4 allele frequency. The results suggest that AD/ALB is pathologically different from AD/LBD, suggesting that it is a neuropathologically distinct and isolated alpha-synucleinopathy.
Authors:
Hirotake Uchikado; Wen-Lang Lin; Michael W DeLucia; Dennis W Dickson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neuropathology and experimental neurology     Volume:  65     ISSN:  0022-3069     ISO Abbreviation:  J. Neuropathol. Exp. Neurol.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-07-07     Completed Date:  2006-08-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  2985192R     Medline TA:  J Neuropathol Exp Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  685-97     Citation Subset:  IM    
Affiliation:
Department of Pathology, Mayo Clinic College of Medicine, Jacksonville, Florida 32224, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Alzheimer Disease / pathology*,  physiopathology
Amygdala / pathology*
Demography
Female
Humans
Lewy Bodies / metabolism,  pathology*,  ultrastructure
Lewy Body Disease / pathology*
Male
Middle Aged
Neurons / metabolism,  pathology,  ultrastructure
Retrospective Studies
Statistics as Topic
alpha-Synuclein / metabolism
Grant Support
ID/Acronym/Agency:
P01-AG03949/AG/NIA NIH HHS; P01-AG14449/AG/NIA NIH HHS; P01-AG17216/AG/NIA NIH HHS; P50-AG16574/AG/NIA NIH HHS; P50-AG25711/AG/NIA NIH HHS; P50-NS40256/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/alpha-Synuclein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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