Document Detail

Alzheimer disease: quantitative H-1 MR spectroscopic imaging of frontoparietal brain.
MedLine Citation:
PMID:  9530304     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To replicate previous hydrogen-1 magnetic resonance (MR) spectroscopic imaging findings of metabolic abnormalities in patients with Alzheimer disease (AD), to verify that metabolic abnormalities are not an artifact of structural variations measured at MR imaging, to determine whether metabolic changes correlate with dementia severity, and to test whether MR imaging and MR spectroscopic imaging findings together improve ability to differentiate AD.
MATERIALS AND METHODS: MR spectroscopic imaging and MR imaging were performed in 28 patients with AD and 22 healthy elderly subjects. Spectroscopic imaging data were coregistered with MR imaging segmentation data to obtain volume-corrected metabolite concentrations.
RESULTS: Consistent with previous results, N-acetyl aspartate (NAA) levels were statistically significantly reduced in frontal and posterior mesial cortex of AD patients, presumably due to neuronal loss. NAA level reductions were independent of structural variations measured at MR imaging and, in parietal mesial cortex, were correlated mildly with dementia severity. Spectroscopic imaging findings of NAA level combined with MR imaging measures did not improve discrimination power for AD relative to that of MR imaging alone.
CONCLUSION: Reduced NAA levels in frontoparietal brain are of limited use for diagnosis of AD. However, they are not an artifact of structural variations and thus may provide useful information for the understanding of the pathologic processes underlying AD.
N Schuff; D L Amend; D J Meyerhoff; J L Tanabe; D Norman; G Fein; M W Weiner
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Radiology     Volume:  207     ISSN:  0033-8419     ISO Abbreviation:  Radiology     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-04-16     Completed Date:  1998-04-16     Revised Date:  2014-09-09    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  91-102     Citation Subset:  AIM; IM    
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MeSH Terms
Aged, 80 and over
Alzheimer Disease / diagnosis*,  metabolism
Aspartic Acid / analogs & derivatives,  analysis
Brain Chemistry*
Choline / analysis
Creatine / analysis
Image Processing, Computer-Assisted
Magnetic Resonance Spectroscopy / diagnostic use*
Middle Aged
Grant Support
R01 AG 10897/AG/NIA NIH HHS; R01 AG010897/AG/NIA NIH HHS; R01 AG010897-12/AG/NIA NIH HHS
Reg. No./Substance:
30KYC7MIAI/Aspartic Acid; 997-55-7/N-acetylaspartate; MU72812GK0/Creatine; N91BDP6H0X/Choline

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