| Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases. | |
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MedLine Citation:
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PMID: 12495843 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gamma-secretase is a pivotal enzymatic activity in Alzheimer disease that was hidden within a huge number of unrelated proteases. Only recently it has become clear that a protease complex containing presenilin, nicastrin, PEN-2 and probably APH-1 provides the long sought gamma-secretase activity. Presenilin itself appears to be a novel polytopic aspartyl protease of the GxGD type, whereas the other components might be required for substrate recognition, complex assembly, stability and targeting of the complex to its sites of action. |
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Authors:
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Christian Haass; Harald Steiner |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Trends in cell biology Volume: 12 ISSN: 0962-8924 ISO Abbreviation: Trends Cell Biol. Publication Date: 2002 Dec |
Date Detail:
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Created Date: 2002-12-23 Completed Date: 2003-10-31 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9200566 Medline TA: Trends Cell Biol Country: England |
Other Details:
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Languages: eng Pagination: 556-62 Citation Subset: IM |
Affiliation:
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Adolf-Butenandt-Institute, Dept of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Ludwig-Maximilians-University Munich, Schillerstr. 44, 80336 Munich, Germany. chaass@pbm.med.uni-muenchen.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alzheimer Disease
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enzymology* Amyloid Precursor Protein Secretases Animals Aspartic Acid Endopeptidases / metabolism* Cell Membrane / enzymology Endopeptidases / metabolism* Membrane Proteins / metabolism* Multienzyme Complexes / metabolism* Presenilin-1 |
| Chemical | |
Reg. No./Substance:
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0/Membrane Proteins; 0/Multienzyme Complexes; 0/Presenilin-1; EC 3.4.-/Amyloid Precursor Protein Secretases; EC 3.4.-/Endopeptidases; EC 3.4.23.-/Aspartic Acid Endopeptidases |
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