Document Detail


Alzheimer A beta vaccination of rhesus monkeys (Macaca mulatta).
MedLine Citation:
PMID:  15195463     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent preliminary data suggest that vaccination with Alzheimer A beta might reduce senile plaque load and stabilize cognitive decline in human Alzheimer disease. To examine the mechanisms and consequences of anti-A beta-antibody formation in a species more closely related to humans, rhesus monkeys (Macaca mulatta) were vaccinated with aggregated A beta 1-42. Immunized monkeys developed anti-A beta titers exceeding 1:1000, and their plasma A beta levels were 5- to 10-fold higher than the plasma A beta levels observed in monkeys vaccinated with aggregated amylin. These data support the use of nonhuman primates to model certain phenomena associated with vaccination of humans with aggregated Alzheimer A beta.
Authors:
Sam Gandy; Ron B DeMattos; Cynthia A Lemere; Frank L Heppner; Jodi Leverone; Adriano Aguzzi; William B Ershler; Jinlu Dai; Paul Fraser; Peter St George Hyslop; David M Holtzman; Lary C Walker; Evan T Keller
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Alzheimer disease and associated disorders     Volume:  18     ISSN:  0893-0341     ISO Abbreviation:  Alzheimer Dis Assoc Disord     Publication Date:    2004 Jan-Mar
Date Detail:
Created Date:  2004-06-15     Completed Date:  2004-06-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8704771     Medline TA:  Alzheimer Dis Assoc Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  44-6     Citation Subset:  IM    
Affiliation:
Farber Institute for Neurosciences, Thomas Jefferson University, 900 Walnut St, Suite 467, Philadelphia, PA 19107, USA. samgandy@earthlink.net
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MeSH Terms
Descriptor/Qualifier:
Amyloid beta-Protein / immunology*,  therapeutic use*
Animals
Antibody Formation
Disease Models, Animal
Female
Immunization / veterinary
Macaca mulatta
Vaccines / immunology*
Chemical
Reg. No./Substance:
0/Amyloid beta-Protein; 0/Vaccines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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