| Alx3-deficient mice exhibit folic acid-resistant craniofacial midline and neural tube closure defects. | |
| | |
MedLine Citation:
|
PMID: 20534379 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Neural tube closure defects are among the most frequent congenital malformations in humans. Supplemental maternal intake of folic acid before and during pregnancy reduces their incidence significantly, but the mechanism underlying this preventive effect is unknown. As a number of genes that cause neural tube closure defects encode transcriptional regulators in mice, one possibility is that folic acid could induce the expression of transcription factors to compensate for the primary genetic defect. We report that folic acid is required in mouse embryos for the specific expression of the homeodomain gene Alx3 in the head mesenchyme, an important tissue for cranial neural tube closure. Alx3-deficient mice exhibit increased failure of cranial neural tube closure and increased cell death in the craniofacial region, two effects that are also observed in wild type embryos developing in the absence of folic acid. Folic acid cannot prevent these defects in Alx3-deficient embryos, indicating that one mechanism of folic acid action is through induced expression of Alx3. Thus, Alx3 emerges as a candidate gene for human neural tube defects and reveals the existence of induced transcription factor gene expression as a previously unknown mechanism by which folic acid prevents neural tube closure defects. |
| | |
Authors:
|
Sita Lakhwani; Patricia García-Sanz; Mario Vallejo |
Related Documents
:
|
467569 - The occurrence of lipid droplets in the proximal and distal tubules of the rat kidney a... 9198109 - Accumulation and distribution of free folic acid content in red beet (beta vulgaris l.). 19549749 - Antenatal micronutrient supplementation reduces metabolic syndrome in 6- to 8-year-old ... 6091439 - Diet, nutrition intake, and metabolism in populations at high and low risk for colon ca... 8927119 - Occurrence of cyclopiazonic acid in feeds and feedstuffs in tamil nadu, india. 8560289 - Periconceptional folic acid supplementation as a social intervention. 2886669 - Sulfasalazine and its metabolites attenuate respiratory burst of leukocytes--a possible... 2061239 - Fatty acid elongation and desaturation enzyme activities of bovine liver and subcutaneo... 10596359 - Formulation development of allopurinol suppositories and injectables. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-06-08 |
Journal Detail:
|
Title: Developmental biology Volume: 344 ISSN: 1095-564X ISO Abbreviation: Dev. Biol. Publication Date: 2010 Aug |
Date Detail:
|
Created Date: 2010-08-02 Completed Date: 2010-08-30 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0372762 Medline TA: Dev Biol Country: United States |
Other Details:
|
Languages: eng Pagination: 869-80 Citation Subset: IM |
Copyright Information:
|
Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
|
Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas/Universidad Autónoma de Madrid, Spain. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals DNA-Binding Proteins / genetics, metabolism Embryo, Mammalian Female Folic Acid / genetics, metabolism*, pharmacology Genotype Hematinics Mesoderm / metabolism Mice Neural Tube Defects / genetics*, prevention & control Neurulation Pregnancy Transcription Factors / genetics, metabolism |
| Chemical | |
Reg. No./Substance:
|
0/DNA-Binding Proteins; 0/Hematinics; 0/Transcription Factors; 59-30-3/Folic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Long-term stability of soluble ST2 in frozen plasma samples.
Next Document: Notch signalling defines critical boundary during budding in Hydra.