Document Detail

Alveolar soft-part sarcoma: evidence for its myogenic origin and for the involvement of 17q25.
MedLine Citation:
PMID:  8314217     Owner:  NLM     Status:  MEDLINE    
A typical case of alveolar soft-part sarcoma was examined using ultrastructural, immunohistochemical and cytogenetic methods. Immunohistochemical stains were performed on frozen sections and showed strong desmin expression with the three anti-desmin antibodies used. In addition, the tumour cells were weakly positive for vimentin and myosin. Neural markers were negative. Chromosomal analysis showed consistent involvement of 17q25--an abnormality which has been reported in another alveolar soft-part sarcoma. The histogenesis of alveolar soft-part sarcoma is still debatable but our findings support a myogenic origin. The finding of an apparently identical chromosomal abnormality in two of three thus far examined cases of alveolar soft-part sarcoma is of interest and must await further confirmation, but it may result in the identification of a chromosomal marker for this enigmatic tumour and thus pave the way for further molecular elucidation.
R Sciot; P Dal Cin; R De Vos; B Van Damme; I De Wever; H Van den Berghe; V J Desmet
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Histopathology     Volume:  23     ISSN:  0309-0167     ISO Abbreviation:  Histopathology     Publication Date:  1993 Nov 
Date Detail:
Created Date:  1994-03-18     Completed Date:  1994-03-18     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7704136     Medline TA:  Histopathology     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  439-44     Citation Subset:  IM    
Department of Pathology, Catholic University of Leuven, Belgium.
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MeSH Terms
Chromosome Aberrations*
Chromosomes, Human, Pair 17*
Desmin / metabolism
Genetic Markers
Microscopy, Electron
Muscles / pathology
Myosins / metabolism
Sarcoma, Alveolar Soft Part / genetics*,  metabolism,  pathology*
Soft Tissue Neoplasms / genetics*,  metabolism,  pathology*
Vimentin / metabolism
Reg. No./Substance:
0/Desmin; 0/Genetic Markers; 0/Vimentin; EC

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