Document Detail

Alveolar recruitment assessed by positron emission tomography during experimental acute lung injury.
MedLine Citation:
PMID:  17047926     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To compare changes in aerated lung volumes measured by positron emission tomography (PET) and inflation volume-pressure curve (V-P) of the respiratory system, and to evaluate the reliability of PET to assess alveolar recruitment. DESIGN AND SETTING: Experimental study in six anesthetized and mechanically ventilated pigs in a PET facility in an experimental university laboratory. INTERVENTIONS: Lung injury was induced by oleic acid. Animals were randomly studied in four conditions: PEEP 0cmH(2)O (ZEEP) in supine position (SP), PEEP 10cmH(2)O in SP, ZEEP in prone position (PP) and PEEP in PP, each applied for 30min. MEASUREMENTS AND RESULTS: With PET aerated lung volume was obtained from pulmonary density analysis using transmission scan (VA(trans)) and from nitrogen-13 kinetics on emission scan (VA(em)). Changes in VA(trans) and VA(em) were computed as the difference in aerated volume between conditions. VA(trans) and VA(em) did not differ between SP and PP, on either ZEEP or PEEP, suggesting no modification in relaxation volume of the respiratory system induced by posture. Changes in VA(trans) or VA(em) were significantly correlated with changes in aerated volume assessed from superimposed V-P curves (R (2)=0.74 and 0.75, respectively). Alveolar recruitment assessed by PET was significantly correlated with both PaO(2) (R (2)=0.61) and PaCO(2) (R (2)=0.40) variations induced by PEEP. CONCLUSIONS: PET is a new reliable tool of scientific interest to image lung volume and alveolar recruitment during acute lung injury.
Jean-Christophe Richard; Didier Le Bars; Nicolas Costes; Fabienne Bregeon; Christian Tourvieille; Franck Lavenne; Marc Janier; Gérard Gimenez; Claude Guerin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-09-19
Journal Detail:
Title:  Intensive care medicine     Volume:  32     ISSN:  0342-4642     ISO Abbreviation:  Intensive Care Med     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-20     Completed Date:  2007-02-23     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1889-94     Citation Subset:  IM    
Service de Réanimation Médicale et d'Assistance Respiratoire, Hôpital de la Croix Rousse, 93 Grande Rue de la Croix Rousse, 69004, Lyon, France.
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MeSH Terms
Lung Volume Measurements
Oleic Acid
Positive-Pressure Respiration*
Positron-Emission Tomography*
Pulmonary Atelectasis / prevention & control*
Pulmonary Gas Exchange
Random Allocation
Respiratory Distress Syndrome, Adult / radionuclide imaging*,  therapy*
Respiratory Function Tests / methods*
Reg. No./Substance:
112-80-1/Oleic Acid
Comment In:
Intensive Care Med. 2006 Nov;32(11):1686-8   [PMID:  17047924 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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