| Alveolar proteinosis as a consequence of immunosuppression. A hypothesis based on clinical and pathologic observations. | |
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MedLine Citation:
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PMID: 7429503 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Eight patients with hematologic malignant disease presented with associated alveolar proteinosis. All but one of these patients also had evidence of opportunistic infections. No explanation for this association could be elicited, but all patients appeared immunosuppressed at the time of their death. Autopsy revealed proteinaceous material or micro-organisms in the alveoli, but the inflammatory response was minimal. Forty cases of opportunistic infections and 22 cases of hematologic malignant disease were found among the patients with alveolar proteinosis reported in the literature. Lungs in these cases also lacked a significant number of inflammatory cells capable of phagocytosis. On the basis of these observations, a hypothesis is formulated to explain alveolar proteinosis as being a result of poor alveolar clearance in immunosuppressed patients. |
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Authors:
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C W Bedrossian; M A Luna; R H Conklin; W C Miller |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Human pathology Volume: 11 ISSN: 0046-8177 ISO Abbreviation: Hum. Pathol. Publication Date: 1980 Sep |
Date Detail:
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Created Date: 1981-01-26 Completed Date: 1981-01-26 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9421547 Medline TA: Hum Pathol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 527-35 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Female Humans Immunosuppressive Agents / adverse effects Infant Leukemia / complications, drug therapy Lymphoma / complications, drug therapy Male Middle Aged Pulmonary Alveolar Proteinosis / chemically induced, immunology*, pathology Respiratory Tract Infections / immunology |
| Chemical | |
Reg. No./Substance:
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0/Immunosuppressive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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