Document Detail


Alveolar macrophages in pulmonary host defence the unrecognized role of apoptosis as a mechanism of intracellular bacterial killing.
MedLine Citation:
PMID:  23841514     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Alveolar macrophages play an essential role in clearing bacteria from the lower airway, as the resident phagocyte alveolar macrophages must both phagocytose and kill bacteria, and if unable to do this completely must co-ordinate an inflammatory response. The decision to escalate the inflammatory response represents the transition between subclinical infection and the development of pneumonia. Alveolar macrophages are well equipped to phagocytose bacteria and have a large phagolysosomal capacity in which ingested bacteria are killed. The rate-limiting step in control of extracellular bacteria, such as Streptococcus pneumoniae, is the capacity of alveolar macrophages to kill ingested bacteria. Therefore, alveolar macrophages complement canonical microbicidal strategies with an additional level of apoptosis-associated killing to help kill ingested bacteria.
Authors:
J D Aberdein; J Cole; M A Bewley; H M Marriott; D H Dockrell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  174     ISSN:  1365-2249     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-10-08     Completed Date:  2013-12-11     Revised Date:  2014-11-04    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  193-202     Citation Subset:  IM    
Copyright Information:
© 2013 British Society for Immunology.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis / immunology
Asymptomatic Diseases
Bacteriolysis
Complement System Proteins / immunology*
Disease Progression
Humans
Immunity, Active
Intracellular Space / immunology
Macrophage Activation
Macrophages, Alveolar / immunology*
Phagocytosis / immunology
Pneumococcal Infections / complications,  immunology*
Pneumonia / etiology,  immunology*
Streptococcus pneumoniae / immunology*
Grant Support
ID/Acronym/Agency:
076945//Wellcome Trust
Chemical
Reg. No./Substance:
9007-36-7/Complement System Proteins
Comments/Corrections

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