Document Detail

Alveolar lymphocytosis in patients with chronic uveitis: relationship to sarcoidosis.
MedLine Citation:
PMID:  11976898     Owner:  NLM     Status:  MEDLINE    
Bronchoalveolar lavage (BAL) is frequently performed in patients with suspected ocular sarcoidosis. This study describes the immunogenetical, immunological, radiological, and functional features of a subclinical alveolar lymphocytosis unrelated to sarcoidosis in patients with chronic uveitis. Two hundred and ten patients with chronic uveitis of unknown origin, who underwent fiber-optic bronchoscopy with BAL as part of a prospective protocol over a three-year period, were evaluable for retrospective analysis. Sixty-five patients had alveolar lymphocytosis: Sarcoidosis was diagnosed in 13 (6%) patients, whereas alveolar lymphocytosis was considered unrelated to sarcoidosis in 52 (25%). Alveolar lymphocytosis unrelated to sarcoidosis was not associated with radiologically detectable interstitial lung disease or pulmonary function impairment. CD4/CD8 lymphocyte ratio was 3.7 +/- 3.0. Total cell count, total lymphocyte, and CD4 lymphocyte percentage were significantly lower when compared with sarcoidosis-related alveolitis (129,000 +/- 80,000 vs. 218,000 +/- 117,000, p <0.05; 33.1% +/- 13.2 vs. 39.7% +/- 13.2, p <0.05; and 54.3% +/- 18.2 vs. 65.4% +/- 10.1, p <0.05, respectively). Patients with alveolar lymphocytosis unrelated to sarcoidosis were older (47.8 +/- 17.7 years vs. 42.7 +/- 14.2 years, p <0.05) and more likely to carry the HLA-B51 allele (19.7% vs. 7.1%, p <0.01) than patients with chronic uveitis without alveolar lymphocytosis. They did not appear to be at risk of developing clinically apparent interstitial lung disease on followup. We conclude that alveolar lymphocytosis is frequently observed in patients with chronic uveitis. It is generally unrelated to sarcoidosis and may then be associated with a distinctive immunogenetic phenotype.
S Jouveshomme; C Fardeau; J F Finet; J P Akakpo; C Beigelman; P L Hoang; J P Derenne
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Lung     Volume:  179     ISSN:  0341-2040     ISO Abbreviation:  Lung     Publication Date:  2001  
Date Detail:
Created Date:  2002-04-26     Completed Date:  2002-06-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7701875     Medline TA:  Lung     Country:  United States    
Other Details:
Languages:  eng     Pagination:  305-17     Citation Subset:  IM    
Department of Respiratory and Critical Care Medicine, Pitié-Salpêtrière Hospital, Assistance Publique des Hôpitaux de Paris, France.
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MeSH Terms
Bronchoalveolar Lavage Fluid / cytology
CD4-CD8 Ratio
Chronic Disease
Lymphocytosis / complications*,  immunology
Middle Aged
Pulmonary Alveoli / pathology
Respiratory Function Tests
Sarcoidosis / complications*,  diagnosis
Uveitis / complications*,  immunology

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