| Alveolar lymphocyte proliferation induced by Propionibacterium acnes in sarcoidosis patients. | |
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MedLine Citation:
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PMID: 3024453 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The proliferation of lymphocytes induced by Propionibacterium acnes (P. acnes) was measured by the in vitro incorporation of 3H-thymidine. The mean response rate of alveolar lymphocytes obtained by bronchoalveolar lavage was 2.23 +/- 0.89 in nine untreated sarcoidosis patients, 0.85 +/- 0.17 in five sarcoidosis patients given corticosteroids and 0.78 +/- 0.29 in 11 controls. The proliferation was significantly enhanced in the untreated patients compared to both the treated patients (p less than 0.01) and controls (p less than 0.001), but there was no significant difference in response rates between the treated patients and controls. The response rate of alveolar lymphocytes was significantly higher in four active patients (3.05 +/- 0.61) than in four inactive patients (1.77 +/- 0.44) (p less than 0.05) and in the controls (p less than 0.001). In sarcoidosis patients, the response rates showed a good correlation with activities of serum lysozyme (r = 0.695, p less than 0.01), and with percentages of lymphocytes in bronchoalveolar lavage fluid (r = 0.591, p less than 0.05). There was a low correlation between angiotensin-converting enzyme activities and the response rates (r = 0.508, p less than 0.1). Neither peripheral blood lymphocytes in sarcoidosis patients nor in controls showed any response to P. acnes, but alveolar lymphocytes of the untreated active sarcoidosis patients were sensitive to P. acnes. The lymphocytes activated by P. acnes may play a central role in the induction of alveolitis in sarcoidosis patients. |
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Authors:
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Y Nakata; T Ejiri; T Kishi; Y Mori; T Hioka; M Kataoka; T Ohnoshi; I Kimura |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta medica Okayama Volume: 40 ISSN: 0386-300X ISO Abbreviation: Acta Med. Okayama Publication Date: 1986 Oct |
Date Detail:
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Created Date: 1986-12-24 Completed Date: 1986-12-24 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0417611 Medline TA: Acta Med Okayama Country: JAPAN |
Other Details:
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Languages: eng Pagination: 257-64 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Bacterial Infections / complications, pathology* Cell Division Female Humans Lymphocytes / microbiology, pathology* Male Middle Aged Muramidase / blood Peptidyl-Dipeptidase A / blood Prednisolone / pharmacology Propionibacterium acnes Pulmonary Alveoli / cytology* Sarcoidosis / complications, microbiology*, pathology |
| Chemical | |
Reg. No./Substance:
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50-24-8/Prednisolone; EC 3.2.1.17/Muramidase; EC 3.4.15.1/Peptidyl-Dipeptidase A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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