Document Detail


Alveolar lymphocyte proliferation induced by Propionibacterium acnes in sarcoidosis patients.
MedLine Citation:
PMID:  3024453     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The proliferation of lymphocytes induced by Propionibacterium acnes (P. acnes) was measured by the in vitro incorporation of 3H-thymidine. The mean response rate of alveolar lymphocytes obtained by bronchoalveolar lavage was 2.23 +/- 0.89 in nine untreated sarcoidosis patients, 0.85 +/- 0.17 in five sarcoidosis patients given corticosteroids and 0.78 +/- 0.29 in 11 controls. The proliferation was significantly enhanced in the untreated patients compared to both the treated patients (p less than 0.01) and controls (p less than 0.001), but there was no significant difference in response rates between the treated patients and controls. The response rate of alveolar lymphocytes was significantly higher in four active patients (3.05 +/- 0.61) than in four inactive patients (1.77 +/- 0.44) (p less than 0.05) and in the controls (p less than 0.001). In sarcoidosis patients, the response rates showed a good correlation with activities of serum lysozyme (r = 0.695, p less than 0.01), and with percentages of lymphocytes in bronchoalveolar lavage fluid (r = 0.591, p less than 0.05). There was a low correlation between angiotensin-converting enzyme activities and the response rates (r = 0.508, p less than 0.1). Neither peripheral blood lymphocytes in sarcoidosis patients nor in controls showed any response to P. acnes, but alveolar lymphocytes of the untreated active sarcoidosis patients were sensitive to P. acnes. The lymphocytes activated by P. acnes may play a central role in the induction of alveolitis in sarcoidosis patients.
Authors:
Y Nakata; T Ejiri; T Kishi; Y Mori; T Hioka; M Kataoka; T Ohnoshi; I Kimura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta medica Okayama     Volume:  40     ISSN:  0386-300X     ISO Abbreviation:  Acta Med. Okayama     Publication Date:  1986 Oct 
Date Detail:
Created Date:  1986-12-24     Completed Date:  1986-12-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0417611     Medline TA:  Acta Med Okayama     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  257-64     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Bacterial Infections / complications,  pathology*
Cell Division
Female
Humans
Lymphocytes / microbiology,  pathology*
Male
Middle Aged
Muramidase / blood
Peptidyl-Dipeptidase A / blood
Prednisolone / pharmacology
Propionibacterium acnes
Pulmonary Alveoli / cytology*
Sarcoidosis / complications,  microbiology*,  pathology
Chemical
Reg. No./Substance:
50-24-8/Prednisolone; EC 3.2.1.17/Muramidase; EC 3.4.15.1/Peptidyl-Dipeptidase A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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