Document Detail


Alveolar air/tissue interface and nuclear magnetic resonance behavior of normal and edematous lungs.
MedLine Citation:
PMID:  7697225     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The alveolar air/tissue interface markedly affects the NMR properties of lungs by causing an NMR signal loss as a result of internal (tissue-induced) magnetic field inhomogeneity. The signal loss can be measured as the difference in NMR signal intensity (difference signal delta) between a pair of images obtained using temporally symmetric and asymmetric spin-echo sequences. Previous data indicate that the difference signal measured at an asymmetry time of 6 ms (delta 6ms) is very low in degassed lungs and increases markedly with alveolar opening. Theoretically, the NMR behavior of edematous lungs is expected to differ from that of normal nondegassed lungs because alveolar flooding and collapse are equivalent to partial (regional) degassing. To test this prediction, we measured delta 6ms in normal and edematous (oleic acid-injured) excised unperfused rat lungs at 5, 10, 20, 30, and 0 (full passive deflation) cm H2O inflation pressure (PL). Lung volume changes were estimated from NMR lung water density (pH2O) measurements. In normal lungs, delta 6ms did not vary with PL. In edematous lungs delta 6ms was, as predicted, significantly lower than normal at 5 and 10 cm H2O PL but rose markedly (to about normal) as PL was further increased. Upon subsequent deflation from 30 to 0 cm H2O PL, delta 6ms did not vary significantly or decreased. On the basis of our theoretical models, the data could be interpreted as reflecting the loss of alveolar air/tissue interface as a result of alveolar flooding and the relative contributions of airspace recruitment and distension to the lung volume changes. Histologic and morphometric data obtained from the same lungs supported this interpretation.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
A G Cutillo; K C Goodrich; K Ganesan; S Watanabe; D C Ailion; A H Morris; C H Durney
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  151     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-05-04     Completed Date:  1995-05-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1018-26     Citation Subset:  AIM; IM    
Affiliation:
Department of Internal Medicine, University of Utah, Salt Lake City.
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MeSH Terms
Descriptor/Qualifier:
Animals
Female
Lung / anatomy & histology*,  pathology,  physiology
Magnetic Resonance Spectroscopy*
Pulmonary Alveoli / pathology*,  physiology
Pulmonary Edema / pathology*,  physiopathology
Rats
Rats, Sprague-Dawley
Respiratory Mechanics*
Grant Support
ID/Acronym/Agency:
HL-31216/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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