Document Detail

Alveolar haemorrhage in a case of high altitude pulmonary oedema.
MedLine Citation:
PMID:  10639537     Owner:  NLM     Status:  MEDLINE    
A case of high altitude pulmonary oedema (HAPE) in a climber who made a rapid ascent on Mt McKinley (Denali), Alaska is described. The bronchoalveolar lavage (BAL) fluid contained increased numbers of red blood cells and an abundance of haemosiderin laden macrophages consistent with alveolar haemorrhage. The timing of this finding indicates that alveolar haemorrhage began early during the ascent, well before the onset of symptoms. Although evidence of alveolar haemorrhage has been reported at necropsy in individuals dying of HAPE, previous reports have not shown the same abundance of haemosiderin laden macrophages in the BAL fluid. These findings suggest that alveolar haemorrhage is an early event in HAPE.
C K Grissom; K H Albertine; M R Elstad
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Thorax     Volume:  55     ISSN:  0040-6376     ISO Abbreviation:  Thorax     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-02-25     Completed Date:  2000-02-25     Revised Date:  2008-11-20    
Medline Journal Info:
Nlm Unique ID:  0417353     Medline TA:  Thorax     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  167-9     Citation Subset:  IM    
Division of Respiratory, Critical Care, and Occupational Pulmonary Medicine, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA.
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MeSH Terms
Altitude Sickness / complications*,  pathology
Bronchoalveolar Lavage Fluid
Erythrocyte Count
Hemorrhage / diagnosis,  etiology*
Hemosiderin / diagnostic use
Macrophages, Alveolar
Pulmonary Alveoli / blood supply*
Pulmonary Edema / etiology*,  pathology
Grant Support
Reg. No./Substance:

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