Document Detail


Alveolar fluid clearance in acute lung injury: what have we learned from animal models and clinical studies?
MedLine Citation:
PMID:  17525842     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Acute lung injury and the acute respiratory distress syndrome continue to be significant causes of morbidity and mortality in the intensive care setting. The failure of patients to resolve the alveolar edema associated with these conditions is a major contributing factor to mortality; hence there is continued interest to understand the mechanisms of alveolar edema fluid clearance.
DISCUSSION: The accompanying review by Vadász et al. details our current understanding of the signaling mechanisms and cellular processes that facilitate clearance of edema fluid from the alveolar compartment, and how these signaling processes may be exploited in the development of novel therapeutic strategies. To complement that report this review focuses on how intact organ and animal models and clinical studies have facilitated our understanding of alveolar edema fluid clearance in acute lung injury and acute respiratory distress syndrome. Furthermore, it considers how what we have learned from these animal and organ models and clinical studies has suggested novel therapeutic avenues to pursue.
Authors:
Rory E Morty; Oliver Eickelberg; Werner Seeger
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2007-05-25
Journal Detail:
Title:  Intensive care medicine     Volume:  33     ISSN:  0342-4642     ISO Abbreviation:  Intensive Care Med     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-07-05     Completed Date:  2008-01-23     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1229-40     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, University of Giessen Lung Center, Justus Liebig University, Klinikstrasse 36, 35392, Giessen, Germany. rory.morty@innere.med.uni-giessen.de
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MeSH Terms
Descriptor/Qualifier:
Animals
Disease Models, Animal
Extravascular Lung Water / metabolism*
Humans
Pulmonary Alveoli / metabolism*
Pulmonary Edema / metabolism
Respiratory Distress Syndrome, Adult / drug therapy,  metabolism*

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