Document Detail


Alveolar epithelial cells: differentiation and lung injury.
MedLine Citation:
PMID:  16423267     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Re-epithelialization of alveolar epithelial cells is one of the important repair processes in many types of lung injury. The major functions of alveolar type II cells are synthesis and secretion of surfactant, hyperplasia in reaction to alveolar epithelial injury, and serving as progenitor cells for alveolar type I cells. The authors have examined the effects of several soluble factors on cultured alveolar type II cells in vitro, and also examined the histopathology and gene expression of surfactant proteins in the rat lungs with LPS, bleomycin and/or treated with keratinocyte growth factor. The authors next examined the effects of bone marrow stromal cells (BMSC) implanted transvenously into bleomycin-induced lungs. The authors found that keratinocyte growth factor (KGF) is a strong growth factor for alveolar type II cells, and that KGF instillation prevents bleomycin-induced lung injury. Furthermore, the authors showed the possibility of differentiation of implanted BMSC into alveolar epithelial cells. KGF and BMSC may play an important role in maintaining the alveolar epithelium and repairing the damaged epithelium after injury, and may well provide potential therapeutic alternatives.
Authors:
Kazuhiro Sugahara; Joho Tokumine; Koji Teruya; Tatsuo Oshiro
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Publication Detail:
Type:  Evaluation Studies; In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Respirology (Carlton, Vic.)     Volume:  11 Suppl     ISSN:  1323-7799     ISO Abbreviation:  Respirology     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-01-20     Completed Date:  2006-06-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9616368     Medline TA:  Respirology     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  S28-31     Citation Subset:  IM    
Affiliation:
Department of Anesthesiology, Faculty of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan. anesthks@med.u-ryukyu.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Bleomycin
Cell Differentiation
Cells, Cultured
Dose-Response Relationship, Drug
Epithelial Cells / drug effects,  metabolism*,  secretion
Fibroblast Growth Factor 7 / pharmacology*
Male
Pulmonary Alveoli / cytology*
Pulmonary Surfactants / metabolism
Rats
Rats, Sprague-Dawley
Respiratory Distress Syndrome, Adult / physiopathology,  therapy*
Stem Cell Transplantation*
Wound Healing / drug effects,  physiology*
Chemical
Reg. No./Substance:
0/Pulmonary Surfactants; 11056-06-7/Bleomycin; 126469-10-1/Fibroblast Growth Factor 7

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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