Document Detail

Alveolar dead space as a predictor of severity of pulmonary embolism.
MedLine Citation:
PMID:  10905639     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine whether the alveolar dead space volume (V(D)alv), expressed as a percentage of the alveolar tidal volume (V(D)alv/V(T)alv), can predict the degree of vascular occlusion caused by pulmonary embolism (PE). METHODS: Fifty-three subjects with suspected PE were prospectively studied. Pulmonary embolism was diagnosed in 33 by high-probability ventilation/perfusion (V/Q) scan (n = 19) or by pulmonary arteriography (PAG, n = 14). Pulmonary embolism was excluded by PAG in 20 subjects. The V(D)alv/V(T)alv was determined from volumetric capnography and arterial blood gas analysis, which permits measurement of the physiologic dead space, V(D)phys (mL) = [(PaCO2 - PeCO2)/PaCO2]. tidal volume. Airway dead space (V(D)aw) was subtracted to yield the alveolar dead space [(V(D)phys - V(D)aw) = V(D)alv (mL)]; the percentage of alveolar volume occupied by alveolar dead space per breath = V(D)alv/V(T)alv x 100%. Percentage perfusion defect was determined from V/Q scans by a radiologist blinded to other data. Regression analysis was performed to show correlation between V(D)alv/V(T)alv and defect on V/Q scan or systolic pulmonary arterial pressure (SPAP). RESULTS: For subjects with PE, the mean perfusion defect on lung scan was 38 +/- 22%; the mean V(D)alv = 208 +/- 115 mL, V(T)alv = 452 +/- 251 mL, and V(D)alv/V(T)alv = 43 +/- 18%. Regression of V(D)alv/V(T)alv vs perfusion defect yielded r2 = 0.41. Regression of V(D)alv/V(T)alv vs pulmonary artery pressures yielded r2 = 0.59. For subjects without PE, V(D)alv/V(T)alv = 27 +/- 14% and V(D)alv = 89 +/- 66 mL. CONCLUSIONS: The V(D)alv/V(T)alv correlates with the lung perfusion defect and the pulmonary artery pressures in subjects with PE. These findings show the potential for V(D)alv/V(T)alv to quantify the embolic burden of PE.
J A Kline; A K Kubin; M M Patel; E J Easton; R A Seupal
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Academic emergency medicine : official journal of the Society for Academic Emergency Medicine     Volume:  7     ISSN:  1069-6563     ISO Abbreviation:  Acad Emerg Med     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-11-13     Completed Date:  2000-11-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9418450     Medline TA:  Acad Emerg Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  611-7     Citation Subset:  IM    
Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28203, USA.
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MeSH Terms
Middle Aged
Predictive Value of Tests
Prospective Studies
Pulmonary Alveoli / physiopathology
Pulmonary Embolism / diagnosis*,  mortality,  physiopathology
Pulmonary Gas Exchange
Regression Analysis
Respiratory Dead Space*
Sensitivity and Specificity
Severity of Illness Index
Survival Rate
Ventilation-Perfusion Ratio

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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