|Alveolar damage in AIDS-related Pneumocystis carinii pneumonia.|
|PMID: 9149569 Owner: NLM Status: MEDLINE|
|OBJECTIVE: Pneumocystis carinii pneumonia is the most common and serious of the pulmonary complications of AIDS. Despite this, many basic aspects in the pathogenesis of HIV-associated P carinii pneumonia are unknown. We therefore undertook a light and electron microscopic study of transbronchial biopsy specimens to compare pathologic features of P carinii pneumonia and other HIV-related lung diseases. DESIGN AND PATIENTS: Thirty-seven consecutive HIV-infected patients undergoing a diagnostic bronchoscopy. RESULTS: P carinii pneumonia was characterized by an increase in inflammation, edema, exudate, fibrosts, type II pneumocyte proliferation, and cellular infiltration of the alveolar wall when compared with other lung diseases (all p < 0.05). Electron microscopy showed apposition of the trophozoite to the type I pneumocyte. Erosion of type I pneumocytes was observed in 13 of 15 patients with P carinii pneumonia, whereas none without P carinii pneumonia had this finding (p < 0.05). Erosion of the type II pneumocyte was not observed. CONCLUSION: Inflammation, interstitial fibrosis, and alveolar epithelial erosion are characteristic features of P carinii pneumonia. The changes may form the pathologic basis for the respiratory failure seen in patients with P carinii pneumonia. Electron microscopy did not show any diagnostie advantage over conventional light microscopy using routine stains.|
|T L Benfield; P Prentø; J Junge; J Vestbo; J D Lundgren|
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|Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't|
|Title: Chest Volume: 111 ISSN: 0012-3692 ISO Abbreviation: Chest Publication Date: 1997 May|
|Created Date: 1997-06-03 Completed Date: 1997-06-03 Revised Date: 2006-11-15|
Medline Journal Info:
|Nlm Unique ID: 0231335 Medline TA: Chest Country: UNITED STATES|
|Languages: eng Pagination: 1193-9 Citation Subset: AIM; IM; X|
|Departments of Infectious Diseases and Pathology, EM Division, University of Copenhagen, Hvidovre Hospital, Denmark.|
|APA/MLA Format Download EndNote Download BibTex|
AIDS-Related Opportunistic Infections
Bronchoalveolar Lavage Fluid / microbiology
Colony Count, Microbial
Coloring Agents / diagnostic use
Cytoplasm / ultrastructure
Edema / pathology
Epithelium / pathology, ultrastructure
Exudates and Transudates
Inflammation / pathology
Lung Diseases / pathology
Organelles / ultrastructure
Pneumocystis / cytology
Pneumocystis Infections / pathology*
Pulmonary Alveoli / pathology*, ultrastructure
Pulmonary Fibrosis / pathology
Respiratory Insufficiency / etiology, pathology
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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