Document Detail


Alveolar cells in cyclophosphamide-induced lung injury. II. Pathogenesis of experimental endogenous lipid pneumonia.
MedLine Citation:
PMID:  10506930     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An ultrastructural and histological study was made to analyse the structural and cellular features of the pulmonary lesions produced in Wistar rats by intraperitoneal (i.p.) administration of cyclophosphamide (two i.p. doses of 150 mg CP/1 kg bw/1 ml PBS). Rats exposed to cyclophosphamide (CP) developed a condition whose morphological picture corresponded to endogenous lipid pneumonia and/or pulmonary alveolar proteinosis-like changes. Damage to the endothelium and neutrophil accumulation in lung vascular bed were found to be potential initiators of endogenous lipid pneumonia-type changes. The possibility of the evolution of the acute lung injury into endogenous lipid pneumonia-type changes and into alveolar proteinosis-like changes was demonstrated. The results of the study supplement the existing theories of pulmonary alveolar proteinosis pathogenesis.
Authors:
S Sulkowski; M Sulkowska
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Histology and histopathology     Volume:  14     ISSN:  0213-3911     ISO Abbreviation:  Histol. Histopathol.     Publication Date:  1999 Oct 
Date Detail:
Created Date:  1999-11-26     Completed Date:  1999-11-26     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8609357     Medline TA:  Histol Histopathol     Country:  SPAIN    
Other Details:
Languages:  eng     Pagination:  1145-52     Citation Subset:  IM    
Affiliation:
Department of Pathological Anatomy, Medical University of Bialystok, Poland. sulek@amb.ac.bialystok.pl
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MeSH Terms
Descriptor/Qualifier:
Animals
Cyclophosphamide / administration & dosage
Disease Models, Animal
Immunosuppressive Agents / administration & dosage
Lung / drug effects,  pathology*
Male
Pneumonia, Lipid / chemically induced,  etiology*,  pathology
Pulmonary Alveolar Proteinosis / chemically induced,  pathology*
Pulmonary Alveoli / drug effects,  pathology*
Rats
Rats, Wistar
Chemical
Reg. No./Substance:
0/Immunosuppressive Agents; 50-18-0/Cyclophosphamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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