| Alveolar and bronchial nitric oxide output in healthy children. | |
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MedLine Citation:
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PMID: 19009623 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Exhaled nitric oxide (NO) concentration is a marker of pulmonary inflammation. It is usually measured at a single exhalation flow rate. However, measuring exhaled NO at multiple flow rates allows assessment of the flow-independent NO parameters: alveolar NO concentration, bronchial NO flux, bronchial wall NO concentration, and bronchial diffusing capacity of NO. Our aim was to determine the flow-independent NO parameters in healthy schoolchildren and to compare two different mathematical approaches. Exhaled NO was measured at four flow rates (10, 50, 100, and 200 ml/sec) in 253 schoolchildren (7-13 years old). Flow-independent NO parameters were calculated with linear method (flows >or=50 ml/sec) and non-linear method (all flows). Sixty-six children (32 boys and 34 girls) with normal spirometry and no history or present symptoms of asthma, allergy, atopy or other diseases were included in the analysis. Median bronchial NO flux was 0.4 nl/sec (mean +/- SD: 0.5 +/- 0.3 nl/sec) and median alveolar NO concentration was 1.9 ppb (2.0 +/- 0.8 ppb) with the linear method. Bronchial NO flux correlated positively with height (r = 0.423; P < 0.001), FEV(1) (r = 0.358; P = 0.003), and FVC (r = 0.359; P = 0.003). With the non-linear method, median bronchial wall NO concentration was 49.6 ppb (68.0 +/- 53.3 ppb) and bronchial diffusing capacity of NO was 10.0 pl/sec/ppb (11.8 +/- 7.5 pl/sec/ppb). The non-linear method gave lower alveolar NO concentration (1.4 [1.5 +/- 0.7] ppb, P < 0.001) and higher bronchial NO flux (0.5 [0.6 +/- 0.3] nl/sec, P < 0.001) than the linear method, but the results were highly correlated between the two methods (r = 0.854 and r = 0.971, P < 0.001). In conclusion, the multiple flow rate method is feasible in children but different mathematical methods give slightly different results. Reference values in healthy children are of value when applying bronchial and alveolar NO parameters in the diagnostics and follow-up of inflammatory lung diseases. |
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Authors:
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Anna Sepponen; Lauri Lehtimäki; Heini Huhtala; Minna Kaila; Hannu Kankaanranta; Eeva Moilanen |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pediatric pulmonology Volume: 43 ISSN: 1099-0496 ISO Abbreviation: Pediatr. Pulmonol. Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-12-01 Completed Date: 2009-04-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8510590 Medline TA: Pediatr Pulmonol Country: United States |
Other Details:
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Languages: eng Pagination: 1242-8 Citation Subset: IM |
Copyright Information:
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(c) 2008 Wiley-Liss, Inc. |
Affiliation:
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The Immunopharmacology Research Group, Medical School, University of Tampere, Tampere, Finland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Breath Tests Bronchi / metabolism* Child Exhalation Feasibility Studies Female Humans Lung Diseases / diagnosis* Male Nitric Oxide / analysis*, metabolism* Pulmonary Alveoli / metabolism* |
| Chemical | |
Reg. No./Substance:
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10102-43-9/Nitric Oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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