Document Detail

Alveolar and bronchial exhaled nitric oxide in chronic obstructive pulmonary disease.
MedLine Citation:
PMID:  20097553     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Fractional exhaled NO (Fe,NO) has yielded inconsistent results in COPD. Measuring exhaled NO at multiple flow rates however, allows to dissect exhaled NO in an alveolar (CAlv,NO) and bronchial (J'aw,NO) fraction, which are claimed to better reflect the bronchial and alveolar inflammation in COPD. We examined whether the use of Fe,NO, CAlv,NO and J'aw,NO may contribute to the clinical diagnosis of COPD.
METHODS: One hundred and fifty one patients were included in this case-control design: 28 healthy nonsmokers, 39 healthy smokers, 55 COPD nonsmokers and 29 COPD smokers. Prior to spirometry, exhaled NO was measured at three different flow rates (50, 100 and 200 ml/s; NIOX-FLEX) from which Fe,NO, CAlv,NO and J'aw,NO were calculated.
RESULTS: Mean Fe,NO, mean CAlv,NO and mean J'aw,NO of healthy individuals were not significantly different from COPD patients and none of these variables correlated with FEV(1). In both healthy and COPD patients, current smoking significantly reduced Fe,NO, J'aw,NO and CAlv,NO. Multivariate analysis demonstrated that in contrast to gender, age, BMI, GOLD stage and the use of inhaled corticosteroids, current smoking was the only variable affecting CAlv,NO. (p=0.0115)
CONCLUSION: We conclude that similar to single breath exhaled NO, exhaled NO at different flow rates does not contribute to the diagnosis of COPD in standard respiratory practice.
An Lehouck; Claudia Carremans; Kristien De Bent; Marc Decramer; Wim Janssens
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Publication Detail:
Type:  Journal Article     Date:  2010-01-25
Journal Detail:
Title:  Respiratory medicine     Volume:  104     ISSN:  1532-3064     ISO Abbreviation:  Respir Med     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-08-05     Completed Date:  2010-12-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8908438     Medline TA:  Respir Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  1020-6     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ltd. All rights reserved.
Respiratory Division, University Hospital Gasthuisberg; Katholieke Universiteit Leuven, Herestraat 49, Bus 706, 3000 Leuven, Belgium.
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MeSH Terms
Biological Markers / metabolism
Bronchi / metabolism,  physiopathology*
Case-Control Studies
Middle Aged
Nitric Oxide / metabolism*
Pulmonary Alveoli / metabolism,  physiopathology*
Pulmonary Disease, Chronic Obstructive / diagnosis*,  metabolism,  physiopathology
Respiratory Function Tests
Smoking / metabolism,  physiopathology*
Reg. No./Substance:
0/Biological Markers; 10102-43-9/Nitric Oxide

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