Document Detail

Alveolar bone loss in liver transplantation patients: relationship with prolonged steroid treatment and parathyroid hormone levels.
MedLine Citation:
PMID:  18028195     Owner:  NLM     Status:  MEDLINE    
AIM: To evaluate the relationship among alveolar bone loss (ABL), bone status and calcium-regulating hormones in liver transplantees. PATIENTS AND METHODS: Twenty-one liver transplantees underwent a full oral examination. The correlations among bone densitometry, bone metabolic status and drug treatment were examined. RESULTS: Twelve patients had osteopenia, and six were osteoporotic. ABL was 4.33+/-2.32 mm (range 0.67-9.92). Parathyroid hormone (PTH) levels ranged from 14 to 106 (mean 55.2+/-26.4). The mean 25(OH)D(3) was 11.68+/-4.7, range 3.5-21.1 ng/ml. Nine patients were vitamin D deficient (<10 ng/ml); none of the patients had 25(OH)D(3) levels > or =30 ng/ml. No correlation was found between ABL and current or total glucocorticoids dose, although there was an inverse relation with the duration of treatment (r =-0.474, p=0.03). A positive correlation was found between ABL, PTH (r =0.419, p=0.059) and hip bone mineral density (BMD) (r=0.482, p=0.027). ABL correlated closely with age, PTH, glucocorticoid treatment (duration) and hip BMD (r =0.810, p=0.004). CONCLUSIONS: The majority of liver transplant patients had insufficient 25(OH)D(3) serum levels. Changes in calcium-regulating hormones and hip BMD were correlated with ABL. Therefore, therapeutic intervention aimed at treating vitamin D deficiency and secondary hyperparathyroidism should be considered in these patients. The benefits of vitamin D treatment in the management of secondary hyperparathyroidism and possible decrease in ABL deserve further evaluation in controlled trials.
Orit Oettinger-Barak; Elena Segal; Eli E Machtei; Shlomi Barak; Yaacov Baruch; Sofia Ish-Shalom
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical periodontology     Volume:  34     ISSN:  0303-6979     ISO Abbreviation:  J. Clin. Periodontol.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-11-21     Completed Date:  2008-02-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0425123     Medline TA:  J Clin Periodontol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  1039-45     Citation Subset:  D; IM    
Periodontal Unit, Department of Oral & Dental Medicine, Rambam Health Care Campus, Haifa, Israel.
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MeSH Terms
Age Factors
Alveolar Bone Loss / chemically induced,  metabolism*,  radiography
Alveolar Process / pathology,  radiography
Bone Density / drug effects
Cross-Sectional Studies
Immunosuppressive Agents / adverse effects*
Liver Transplantation / adverse effects*
Mandibular Diseases / chemically induced,  metabolism,  radiography
Maxillary Diseases / chemically induced,  metabolism,  radiography
Middle Aged
Parathyroid Hormone / blood*
Regression Analysis
Steroids / adverse effects*
Time Factors
Reg. No./Substance:
0/Immunosuppressive Agents; 0/Parathyroid Hormone; 0/Steroids

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