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Aluminum may mediate Alzheimer's disease through liver toxicity, with aberrant hepatic synthesis of ceruloplasmin and ATPase7B, the resultant excess free copper causing brain oxidation, beta-amyloid aggregation and Alzheimer disease.
MedLine Citation:
PMID:  23261179     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Aluminum may cause hepatotoxicity with subsequent aberrant synthesis of proteins mediating copper homeostasis, such as ceruloplasmin and ATPase7B with resultant excess free copper, resulting in brain oxidation, protein degradation and beta-amyloid aggregation, all features of Alzheimer disease. Correcting hepatotoxicity might enable prevention or treatment of Alzheimer disease.
Authors:
Steven Brenner
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Publication Detail:
Type:  LETTER     Date:  2012-12-20
Journal Detail:
Title:  Medical hypotheses     Volume:  -     ISSN:  1532-2777     ISO Abbreviation:  Med. Hypotheses     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Saint Louis University, Department of Neurology and Psychiatry, Saint Louis, MI 63104, United States. Electronic address: SBren20979@aol.com.
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