| Aluminum localization in bone from hemodialyzed patients: relationship to matrix mineralization. | |
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MedLine Citation:
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PMID: 7300127 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It has been suggested that in uremic bone, aluminum interferes with normal mineralization. Aluminum content and aluminum localization were studied in iliac crest biopsies of two groups of patients on regular hemodialysis; one group had histologic osteomalacia, and little or no bone resorption (group 1); the other, osteitis fibrosa and no mineralization defect (group 2). Group 1 patients had significantly higher plasma aluminum concentrations than those of group 2. No difference was found in bone aluminum content, which was above normal in both groups. In the bone samples of the osteomalacic subjects, aluminum was mainly localized at the limit between osteoid and calcified tissue, the site where the bone mineral is normally first deposited. Osteomalacia could not be related to hypocalcemia or to phosphate depletion. Active vitamin D derivatives (25-hydroxycholecalciferol and 1alpha-hydroxycholecalciferol) failed to prevent or to improve the bone disease. In the bone samples of group 2 subjects, aluminum could not be localized by the methods used, except in the two cases with greatly elevated bone aluminum, where it was mainly localized on cement lines. In group 2 subjects, immunoreactive parathyroid hormone plasma concentration, osteoclast surface, and marrow fibrosis were significantly higher than they were in group 1 subjects. It is concluded that in bone from uremic patients on regular dialysis, aluminum can induce a particular form of osteomalacia, resistant to the vitamin D active derivatives. The bone disease is only observed in the absence of severe secondary hyperparathyroidism. This suggests that parathyroid hormone may be involved in the development of the aluminum-induced mineralization defect. |
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Authors:
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G Cournot-Witmer; J Zingraff; J J Plachot; F Escaig; R Lefèvre; P Boumati; A Bourdeau; M Garabédian; P Galle; R Bourdon; T Drüeke; S Balsan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Kidney international Volume: 20 ISSN: 0085-2538 ISO Abbreviation: Kidney Int. Publication Date: 1981 Sep |
Date Detail:
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Created Date: 1982-01-20 Completed Date: 1982-01-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0323470 Medline TA: Kidney Int Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 375-8 Citation Subset: IM; S |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aluminum / analysis*, poisoning Biopsy Bone Resorption Bone and Bones / analysis, metabolism*, pathology* Female Fibrous Dysplasia of Bone / metabolism Humans Male Middle Aged Minerals / metabolism* Osteomalacia / drug therapy, etiology*, metabolism Renal Dialysis* / adverse effects Uremia / metabolism, therapy Vitamin D / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Minerals; 1406-16-2/Vitamin D; 7429-90-5/Aluminum |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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