Document Detail

Aluminum induces chromosome aberrations, micronuclei, and cell cycle dysfunction in root cells of Vicia faba.
MedLine Citation:
PMID:  19274764     Owner:  NLM     Status:  MEDLINE    
Aluminum (Al) exists naturally in air, water, and soil, and also in our diet. Al can be absorbed into the human body and accumulates in different tissues, which has been linked to the occurrence of Alzheimer's disease and various neurological disorders. By using Vicia cytogenetic tests, which are commonly used to monitor the genotoxicity of environmental pollutants, cytogenetic effects of aluminum (AlCl(3)) were investigated in this study. Present results showed that Al caused significant increases in the frequencies of micronuclei (MN) and anaphase chromosome aberrations in Vicia faba root tips exposed to Al over a concentration-tested range of 0.01-10 mM for 12 h. The frequency of micronucleated cells was higher in Al-treated groups at pH 4.5 than that at pH 5.8. Similarly, AlCl(3) treatment caused a decrease in the number of mitotic cells in a dose- and pH-dependent manner. The number of cells in each mitotic phase changed in Al-treated samples. Mitotic indices (MI) decreased with the increases of pycnotic cells. Our results demonstrate that aluminum chloride is a clear clastogenic/genotoxic and cytotoxic agent in Vicia root cells. The V. faba cytogenetic test could be used for the genotoxicity monitoring of aluminum water contamination.
Min Yi; Huilan Yi; Honghai Li; Lihua Wu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Environmental toxicology     Volume:  25     ISSN:  1522-7278     ISO Abbreviation:  Environ. Toxicol.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-15     Completed Date:  2010-04-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100885357     Medline TA:  Environ Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  124-9     Citation Subset:  IM    
School of Life Science and Technology, Shanxi University, Taiyuan 030006, China.
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MeSH Terms
Aluminum Compounds / toxicity*
Cell Cycle / drug effects*
Chlorides / toxicity*
Chromosome Aberrations / chemically induced*
Environmental Pollutants / toxicity*
Micronuclei, Chromosome-Defective / chemically induced*
Micronucleus Tests
Mitotic Index
Mutagens / toxicity
Plant Roots / drug effects*
Vicia faba / drug effects*
Reg. No./Substance:
0/Aluminum Compounds; 0/Chlorides; 0/Environmental Pollutants; 0/Mutagens; 7446-70-0/aluminum chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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