| Aluminum chloride stimulates NACl-dependent release of taurine and ?-aminobutyric acid in rat cortical astrocytes. | |
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MedLine Citation:
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PMID: 20504685 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The release of preloaded radiolabeled taurine (TAU) and ?-aminobutyric acid (GABA) from cultured rat cortical astrocytes was monitored 15 min before and 30 min after pulse treatment with aluminum chloride, at 5 min intervals. AlCl(3) at concentrations ranging from 0.125 to 1 mM stimulated TAU release to 252 and 519%, respectively, in a relatively dose-dependent manner. Release of GABA was not affected by 0.5 mM but was almost doubled by 1 mM AlCl(3). The effects of AlCl(3) were greatly diminished or abolished when isotonic sucrose was substituted for NaCl in the superfusion media. Interaction of Al(3+) ions with membrane transporters of amino acids is suggested to account for their increased release. Possible neurophysiological consequences of the acute effects of aluminum on the neuroactive amino acid transport in astrocytes are discussed. |
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Authors:
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J Albrecht; M D Norenberg |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neurochemistry international Volume: 18 ISSN: 0197-0186 ISO Abbreviation: Neurochem. Int. Publication Date: 1991 |
Date Detail:
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Created Date: 2010-05-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8006959 Medline TA: Neurochem Int Country: England |
Other Details:
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Languages: eng Pagination: 125-9 Citation Subset: - |
Affiliation:
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Veteran Administration Medical Center, Department of Pathology, University of Miami School of Medicine-Jackson Memorial Hospital, Miami, FL 33101, U.S.A. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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