Document Detail


Aluminum bioavailability from tea infusion.
MedLine Citation:
PMID:  18848597     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objective was to estimate oral Al bioavailability from tea infusion in the rat, using the tracer (26)Al. (26)Al citrate was injected into tea leaves. An infusion was prepared from the dried leaves and given intra-gastrically to rats which received concurrent intravenous (27)Al infusion. Oral Al bioavailability (F) was calculated from the area under the (26)Al, compared to (27)Al, serum concentration x time curves. Bioavailability from tea averaged 0.37%; not significantly different from water (F=0.3%), or basic sodium aluminum phosphate (SALP) in cheese (F=0.1-0.3%), but greater than acidic SALP in a biscuit (F=0.1%). Time to maximum serum (26)Al concentration was 1.25, 1.5, 8 and 4.8h, respectively. These results of oral Al bioavailability x daily consumption by the human suggest tea can provide a significant amount of the Al that reaches systemic circulation. This can allow distribution to its target organs of toxicity, the central nervous, skeletal and hematopoietic systems. Further testing of the hypothesis that Al contributes to Alzheimer's disease may be more warranted with studies focusing on total average daily food intake, including tea and other foods containing appreciable Al, than drinking water.
Authors:
Robert A Yokel; Rebecca L Florence
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2008-09-21
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  46     ISSN:  0278-6915     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-21     Completed Date:  2009-01-26     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  3659-63     Citation Subset:  IM    
Affiliation:
Department of Pharmaceutical Sciences, University of Kentucky Academic Medical Center, Lexington, KY 40536-0082, USA. ryokel@email.uky.edu
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MeSH Terms
Descriptor/Qualifier:
Aluminum / pharmacokinetics*
Animals
Biological Availability
Data Interpretation, Statistical
Dietary Proteins / analysis
Male
Radioisotopes / pharmacokinetics*
Rats
Rats, Inbred F344
Spectrophotometry, Atomic
Tea / chemistry*
Grant Support
ID/Acronym/Agency:
R01 ES011305-03/ES/NIEHS NIH HHS; R01 ES11305/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Dietary Proteins; 0/Radioisotopes; 0/Tea; 7429-90-5/Aluminum
Comments/Corrections

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