| Aluminum bioavailability from tea infusion. | |
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MedLine Citation:
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PMID: 18848597 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective was to estimate oral Al bioavailability from tea infusion in the rat, using the tracer (26)Al. (26)Al citrate was injected into tea leaves. An infusion was prepared from the dried leaves and given intra-gastrically to rats which received concurrent intravenous (27)Al infusion. Oral Al bioavailability (F) was calculated from the area under the (26)Al, compared to (27)Al, serum concentration x time curves. Bioavailability from tea averaged 0.37%; not significantly different from water (F=0.3%), or basic sodium aluminum phosphate (SALP) in cheese (F=0.1-0.3%), but greater than acidic SALP in a biscuit (F=0.1%). Time to maximum serum (26)Al concentration was 1.25, 1.5, 8 and 4.8h, respectively. These results of oral Al bioavailability x daily consumption by the human suggest tea can provide a significant amount of the Al that reaches systemic circulation. This can allow distribution to its target organs of toxicity, the central nervous, skeletal and hematopoietic systems. Further testing of the hypothesis that Al contributes to Alzheimer's disease may be more warranted with studies focusing on total average daily food intake, including tea and other foods containing appreciable Al, than drinking water. |
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Authors:
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Robert A Yokel; Rebecca L Florence |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2008-09-21 |
Journal Detail:
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Title: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Volume: 46 ISSN: 0278-6915 ISO Abbreviation: Food Chem. Toxicol. Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-11-21 Completed Date: 2009-01-26 Revised Date: 2010-09-21 |
Medline Journal Info:
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Nlm Unique ID: 8207483 Medline TA: Food Chem Toxicol Country: England |
Other Details:
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Languages: eng Pagination: 3659-63 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutical Sciences, University of Kentucky Academic Medical Center, Lexington, KY 40536-0082, USA. ryokel@email.uky.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aluminum
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pharmacokinetics* Animals Biological Availability Data Interpretation, Statistical Dietary Proteins / analysis Male Radioisotopes / pharmacokinetics* Rats Rats, Inbred F344 Spectrophotometry, Atomic Tea / chemistry* |
| Grant Support | |
ID/Acronym/Agency:
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R01 ES011305-03/ES/NIEHS NIH HHS; R01 ES11305/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Dietary Proteins; 0/Radioisotopes; 0/Tea; 7429-90-5/Aluminum |
| Comments/Corrections | |
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