Document Detail

Aluminum bioavailability from the approved food additive leavening agent acidic sodium aluminum phosphate, incorporated into a baked good, is lower than from water.
MedLine Citation:
PMID:  16949191     Owner:  NLM     Status:  MEDLINE    
There are estimates of oral aluminum (Al) bioavailability from drinking water, but little information on Al bioavailability from foods. Foods contribute approximately 95% and drinking water 1-2% of the typical human's daily Al intake. The objectives were to estimate oral Al bioavailability from a representative food containing the food additive acidic sodium aluminum phosphate (acidic SALP), a leavening agent in baked goods. Rats were acclimated to a special diet that resulted in no stomach contents 14 h after its withdrawal. They were trained to rapidly consume a biscuit containing 1.5% acidic SALP. Oral Al bioavailability was then determined from a biscuit containing 1% or 2% acidic SALP, synthesized to contain (26)Al. The rats received concurrent (27)Al infusion. Blood was repeatedly withdrawn and serum analyzed for (26)Al by accelerator mass spectrometry. Total Al was determined by atomic absorption spectrometry. Oral (26)Al bioavailability was determined from the area under the (26)Al, compared to (27)Al, serum concentrationxtime curves. Oral Al bioavailability (F) from biscuit containing 1% or 2% acidic (26)Al-SALP averaged approximately 0.11% and 0.13%; significantly less than from water, which was previously shown to be approximately 0.3%. The time to maximum serum (26)Al concentration was 4.2 and 6h after consumption of biscuit containing 1% or 2% (26)Al-acidic SALP, respectively, compared to 1-2h following (26)Al in water. These results of oral Al bioavailability from acidic (26)Al-SALP in a biscuit (F approximately 0.1%) and results from (26)Al in water (F approximately 0.3%) x the contributions of food and drinking water to the typical human's daily Al intake ( approximately 5-10mg from food and 0.1mg from water, respectively) suggest food provides approximately 25-fold more Al to systemic circulation, and potential Al body burden, than does drinking water.
Robert A Yokel; Rebecca L Florence
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2006-07-21
Journal Detail:
Title:  Toxicology     Volume:  227     ISSN:  0300-483X     ISO Abbreviation:  Toxicology     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-09-25     Completed Date:  2006-11-29     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  0361055     Medline TA:  Toxicology     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  86-93     Citation Subset:  IM    
Pharmaceutical Sciences Department, College of Pharmacy, University of Kentucky Medical Center, 725 Rose Street, Lexington, KY 40536-0082, USA. <>
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MeSH Terms
Aluminum Compounds / blood,  chemistry,  pharmacokinetics*
Animal Feed
Biological Availability
Food Additives / chemistry,  pharmacokinetics*
Hydrogen-Ion Concentration
Phosphates / blood,  chemistry,  pharmacokinetics*
Rats, Inbred F344
Sodium Compounds / blood,  chemistry,  pharmacokinetics*
Spectrophotometry, Atomic
Water / chemistry*
Grant Support
Reg. No./Substance:
0/Aluminum Compounds; 0/Food Additives; 0/Phosphates; 0/Radioisotopes; 0/Sodium Compounds; 7732-18-5/Water; 7785-88-8/aluminum sodium phosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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