| Aluminium-related osteodystrophy and desferrioxamine treatment: role of phosphorus. | |
| | |
MedLine Citation:
|
PMID: 7970094 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We investigated (1) the prevalence of aluminium overload among 96 patients with symptomatic bone disease haemodialysed from 1987 to 1989 in the Sao Paulo area, Brazil; (2) the effect of 6 months desferrioxamine (DFO) treatment (1-2g/week). All patients underwent a first bone biopsy. Aluminium overload (extent of stainable bone aluminium more than 20% trabecular surface) was observed in 74 of 96 patients. Forty overloaded patients were divided into patients with high bone formation rate (BFR) (group 1; n = 17) and patients with low BFR (group 2; n = 23), and had a second biopsy after DFO therapy. In both groups aluminium surface was reduced after treatment (P < 0.001), osteoblast surface (P < 0.02-P < 0.01) and plasma parathyroid hormone (iPTH) (P < 0.01) increased. In group 1 BFR remained high. In group 2 BFR remained low in 16 patients (2a) and increased in seven (P < 0.02) (2b). In group 2a plasma phosphorus was below that in group 2b patients, before (P < 0.03) and after (P < 0.01) DFO. The histological features of group 2a patients resembled hypophosphataemic osteomalacia, those of group 2b patients aluminium osteodystrophy. These data show a high prevalence of aluminium overload in Brazilian patients. Low-dose DFO therapy was safe, decreased bone pain, prevented fractures, and reduced stainable bone aluminium. Bone lesions only partially improved, suggesting that low phosphorus intake and/or plasma calcitriol concentrations may have prevented improvement of bone formation and mineralization. |
| | |
Authors:
|
V Jorgetti; N M Soeiro; V Mendes; R C Pereira; M E Crivellari; G Coutris; A Borelli; M O Leite; I Nussenzweig; M Marcondes |
Related Documents
:
|
12576454 - Real-time analysis of tyrosine hydroxylase gene expression: a sensitive and semiquantit... 19091894 - Bone scintigraphy and spect/ct of bisphosphonate-induced osteonecrosis of the jaw. 10320994 - Photopenic lesions in bone marrow scintigraphy using technetium-99m labeled antigranulo... 17003614 - Association between osteonecrosis of the jaws and chronic high-dosage intravenous bisph... 19167594 - Antihypertensive efficacy and tolerability of irbesartan/hydrochlorothiazide in hyperte... 17804024 - Colour knowledge in semantic dementia: it is not all black and white. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association Volume: 9 ISSN: 0931-0509 ISO Abbreviation: Nephrol. Dial. Transplant. Publication Date: 1994 |
Date Detail:
|
Created Date: 1994-11-29 Completed Date: 1994-11-29 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8706402 Medline TA: Nephrol Dial Transplant Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 668-74 Citation Subset: IM |
Affiliation:
|
Laboratorie de Fisiopatologia Renal, Facultade de Medicina, Universidade de Sao Paulo, Brazil. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Alkaline Phosphatase / blood Aluminum / analysis*, blood Bone Remodeling / drug effects* Calcium / blood Deferoxamine / therapeutic use* Female Humans Ilium / chemistry, pathology* Male Middle Aged Parathyroid Hormone / blood Phosphorus / blood, metabolism* Renal Dialysis / adverse effects Renal Osteodystrophy / blood, drug therapy, etiology* |
| Chemical | |
Reg. No./Substance:
|
0/Parathyroid Hormone; 70-51-9/Deferoxamine; 7429-90-5/Aluminum; 7440-70-2/Calcium; 7723-14-0/Phosphorus; EC 3.1.3.1/Alkaline Phosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cells surrounding haemodialysis-associated amyloid deposits are mainly macrophages.
Next Document: Choice of dialysis membrane does not influence the outcome of residual renal function in haemodialys...